Advanced

The evolution of immunity in relation to colonization and migration

O’Connor, Emily A. LU ; Cornwallis, Charlie K. LU ; Hasselquist, Dennis LU ; Nilsson, Jan Åke LU and Westerdahl, Helena LU (2018) In Nature Ecology and Evolution 2(5). p.841-849
Abstract

Colonization and migration have a crucial effect on patterns of biodiversity, with disease predicted to play an important role in these processes. However, evidence of the effect of pathogens on broad patterns of colonization and migration is limited. Here, using phylogenetic analyses of 1,311 species of Afro-Palaearctic songbirds, we show that colonization events from regions of high (sub-Saharan Africa) to low (the Palaearctic) pathogen diversity were up to 20 times more frequent than the reverse, and that migration has evolved 3 times more frequently from African- as opposed to Palaearctic-resident species. We also found that resident species that colonized the Palaearctic from Africa, as well as African species that evolved... (More)

Colonization and migration have a crucial effect on patterns of biodiversity, with disease predicted to play an important role in these processes. However, evidence of the effect of pathogens on broad patterns of colonization and migration is limited. Here, using phylogenetic analyses of 1,311 species of Afro-Palaearctic songbirds, we show that colonization events from regions of high (sub-Saharan Africa) to low (the Palaearctic) pathogen diversity were up to 20 times more frequent than the reverse, and that migration has evolved 3 times more frequently from African- as opposed to Palaearctic-resident species. We also found that resident species that colonized the Palaearctic from Africa, as well as African species that evolved long-distance migration to breed in the Palaearctic, have reduced diversity of key immune genes associated with pathogen recognition (major histocompatibility complex class I). These results suggest that changes in the pathogen community that occur during colonization and migration shape the evolution of the immune system, potentially by adjusting the trade-off between the benefits of extensive pathogen recognition and the costs of immunopathology that result from high major histocompatibility complex class I diversity.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Ecology and Evolution
volume
2
issue
5
pages
841 - 849
publisher
Nature Publishing Group
external identifiers
  • scopus:85045112453
DOI
10.1038/s41559-018-0509-3
language
English
LU publication?
yes
id
dadf5bd9-bfd8-4c5f-8f62-91744b17cd14
date added to LUP
2018-04-17 14:29:04
date last changed
2019-04-10 04:06:48
@article{dadf5bd9-bfd8-4c5f-8f62-91744b17cd14,
  abstract     = {<p>Colonization and migration have a crucial effect on patterns of biodiversity, with disease predicted to play an important role in these processes. However, evidence of the effect of pathogens on broad patterns of colonization and migration is limited. Here, using phylogenetic analyses of 1,311 species of Afro-Palaearctic songbirds, we show that colonization events from regions of high (sub-Saharan Africa) to low (the Palaearctic) pathogen diversity were up to 20 times more frequent than the reverse, and that migration has evolved 3 times more frequently from African- as opposed to Palaearctic-resident species. We also found that resident species that colonized the Palaearctic from Africa, as well as African species that evolved long-distance migration to breed in the Palaearctic, have reduced diversity of key immune genes associated with pathogen recognition (major histocompatibility complex class I). These results suggest that changes in the pathogen community that occur during colonization and migration shape the evolution of the immune system, potentially by adjusting the trade-off between the benefits of extensive pathogen recognition and the costs of immunopathology that result from high major histocompatibility complex class I diversity.</p>},
  author       = {O’Connor, Emily A. and Cornwallis, Charlie K. and Hasselquist, Dennis and Nilsson, Jan Åke and Westerdahl, Helena},
  language     = {eng},
  number       = {5},
  pages        = {841--849},
  publisher    = {Nature Publishing Group},
  series       = {Nature Ecology and Evolution},
  title        = {The evolution of immunity in relation to colonization and migration},
  url          = {http://dx.doi.org/10.1038/s41559-018-0509-3},
  volume       = {2},
  year         = {2018},
}