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Novel metabolites from the roots of Cadaba natalensis

Monjane, J. A. LU ; Uamusse, A. and Sterner, O. LU (2016) In Phytochemistry Letters 16. p.283-286
Abstract

From an extract of the roots of Cadaba natalensis Sond. the novel macrocyclic dibenzo-diazacyclododecanedione 1 was isolated together with (S)-2-ethyl-2-methyloxazolidin-5-one (2a). In addition, the five known compounds were obtained. Of these, (R)-5-ethyl-5-methyloxazolidin-2-one (3) is reported as a natural product for the first time. The structures of the isolated compounds were elucidated by analysis of the spectral data, 1D NMR (1H, 13C, and DEPT), 2D NMR (COSY, HMQC, HMBC, and NOESY), and HRESIMS, as well as by the comparison with previously reported data.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cadaba natalensis, Diazacyclododecanedione, Isolation, Isoquiniline alkaloids, Oxazolidinone, Structure elucidation
in
Phytochemistry Letters
volume
16
pages
4 pages
publisher
Elsevier
external identifiers
  • scopus:84977613805
  • wos:000378027300050
ISSN
1874-3900
DOI
10.1016/j.phytol.2016.05.009
language
English
LU publication?
yes
id
daece9fb-3486-426a-8d97-233f79da4ffb
date added to LUP
2017-01-25 13:40:04
date last changed
2017-09-18 11:33:55
@article{daece9fb-3486-426a-8d97-233f79da4ffb,
  abstract     = {<p>From an extract of the roots of Cadaba natalensis Sond. the novel macrocyclic dibenzo-diazacyclododecanedione 1 was isolated together with (S)-2-ethyl-2-methyloxazolidin-5-one (2a). In addition, the five known compounds were obtained. Of these, (R)-5-ethyl-5-methyloxazolidin-2-one (3) is reported as a natural product for the first time. The structures of the isolated compounds were elucidated by analysis of the spectral data, 1D NMR (<sup>1</sup>H, <sup>13</sup>C, and DEPT), 2D NMR (COSY, HMQC, HMBC, and NOESY), and HRESIMS, as well as by the comparison with previously reported data.</p>},
  author       = {Monjane, J. A. and Uamusse, A. and Sterner, O.},
  issn         = {1874-3900},
  keyword      = {Cadaba natalensis,Diazacyclododecanedione,Isolation,Isoquiniline alkaloids,Oxazolidinone,Structure elucidation},
  language     = {eng},
  month        = {06},
  pages        = {283--286},
  publisher    = {Elsevier},
  series       = {Phytochemistry Letters},
  title        = {Novel metabolites from the roots of Cadaba natalensis},
  url          = {http://dx.doi.org/10.1016/j.phytol.2016.05.009},
  volume       = {16},
  year         = {2016},
}