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Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation

Bekassy, Zivile LU ; Lopatko Fagerström, Ingrid LU ; Bader, Michael and Karpman, Diana LU orcid (2022) In Nature Reviews Immunology 22(7). p.411-428
Abstract

During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that... (More)

During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Reviews Immunology
volume
22
issue
7
pages
411 - 428
publisher
Nature Publishing Group
external identifiers
  • pmid:34759348
  • scopus:85118876729
ISSN
1474-1733
DOI
10.1038/s41577-021-00634-8
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, Springer Nature Limited.
id
db1d740a-473a-4724-aa66-5cc127740fb3
date added to LUP
2021-12-02 15:33:43
date last changed
2024-04-20 18:00:43
@article{db1d740a-473a-4724-aa66-5cc127740fb3,
  abstract     = {{<p>During severe inflammatory and infectious diseases, various mediators modulate the equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review describes the interactive roles of the renin–angiotensin system, the complement system, and the closely linked kallikrein–kinin and contact systems in cell biological functions such as vascular tone and leakage, inflammation, chemotaxis, thrombosis and cell proliferation. Specific attention is given to the role of these systems in systemic inflammation in the vasculature and tissues during hereditary angioedema, cardiovascular and renal glomerular disease, vasculitides and COVID-19. Moreover, we discuss the therapeutic implications of these complex interactions, given that modulation of one system may affect the other systems, with beneficial or deleterious consequences.</p>}},
  author       = {{Bekassy, Zivile and Lopatko Fagerström, Ingrid and Bader, Michael and Karpman, Diana}},
  issn         = {{1474-1733}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{411--428}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Reviews Immunology}},
  title        = {{Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation}},
  url          = {{http://dx.doi.org/10.1038/s41577-021-00634-8}},
  doi          = {{10.1038/s41577-021-00634-8}},
  volume       = {{22}},
  year         = {{2022}},
}