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The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest

Gilje, Patrik LU ; Frydland, Martin; Bro-Jeppesen, John; Dankiewicz, Josef LU ; Friberg, Hans LU ; Rundgren, Malin LU ; Devaux, Yvan; Stammet, Pascal; Al-Mashat, Mariam LU and Jögi, Jonas LU , et al. (2018) In Biomarkers
Abstract

Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In... (More)

Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.

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keywords
bystander CPR, cardiac arrest, lactate, outcome, Plasma microRNA, shock
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Biomarkers
publisher
Taylor & Francis
external identifiers
  • scopus:85052304532
ISSN
1354-750X
DOI
10.1080/1354750X.2018.1499804
language
English
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yes
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db7ac51f-2279-4afc-98d6-95ef838e2fe9
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2018-10-04 11:03:05
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2019-02-20 11:28:50
@article{db7ac51f-2279-4afc-98d6-95ef838e2fe9,
  abstract     = {<p>Background: Data suggests that the plasma levels of the liver-specific miR-122-5p might both be a marker of cardiogenic shock and a prognostic marker of out-of-hospital cardiac arrest (OHCA). Our aim was to characterize plasma miR-122-5p at admission after OHCA and to assess the association between miR-122-5p and relevant clinical factors such all-cause mortality and shock at admission after OHCA. Methods: In the pilot trial, 10 survivors after OHCA were compared to 10 age- and sex-matched controls. In the main trial, 167 unconscious survivors of OHCA from the Targeted Temperature Management (TTM) trial were included. Results: In the pilot trial, plasma miR-122-5p at admission after OHCA was 400-fold elevated compared to controls. In the main trial, plasma miR-122-5p at admission was independently associated with lactate and bystander cardiopulmonary resuscitation. miR-122-5p at admission was not associated with shock at admission (p = 0.14) or all-cause mortality (p = 0.35). Target temperature (33 °C vs 36 °C) was not associated with miR-122-5p levels at any time point. Conclusions: After OHCA, miR-122-5p demonstrated a marked acute increase in plasma and was independently associated with lactate and bystander resuscitation. However, miR-122-5p at admission was not associated with all-cause mortality or shock at admission.</p>},
  author       = {Gilje, Patrik and Frydland, Martin and Bro-Jeppesen, John and Dankiewicz, Josef and Friberg, Hans and Rundgren, Malin and Devaux, Yvan and Stammet, Pascal and Al-Mashat, Mariam and Jögi, Jonas and Kjaergaard, Jesper and Hassager, Christian and Erlinge, David},
  issn         = {1354-750X},
  keyword      = {bystander CPR,cardiac arrest,lactate,outcome,Plasma microRNA,shock},
  language     = {eng},
  month        = {08},
  publisher    = {Taylor & Francis},
  series       = {Biomarkers},
  title        = {The association between plasma miR-122-5p release pattern at admission and all-cause mortality or shock after out-of-hospital cardiac arrest},
  url          = {http://dx.doi.org/10.1080/1354750X.2018.1499804},
  year         = {2018},
}