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Familial hypercholesterolaemia : cholesterol efflux and coronary disease

Versmissen, Jorie; Vongpromek, Ranitha; Yahya, Reyhana; van der Net, Jeroen B.; van Vark-van der Zee, Leonie; Blommesteijn-Touw, Jeannette; Wattimena, Darcos; Rietveld, Trinet; Pullinger, Clive R. and Christoffersen, Christina, et al. (2016) In European Journal of Clinical Investigation 46(7). p.643-650
Abstract

Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the... (More)

Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers. Conclusions: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.

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published
subject
keywords
Apolipoprotein M, cholesterol efflux, familial hypercholesterolaemia, high-density lipoprotein, sphingolipids, sphingosine-phosphate
in
European Journal of Clinical Investigation
volume
46
issue
7
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84976595523
ISSN
0014-2972
DOI
10.1111/eci.12643
language
English
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yes
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dbc53fbe-68cf-454c-bd3a-e7aa5f5095ae
date added to LUP
2017-01-24 12:40:10
date last changed
2017-10-22 05:25:29
@article{dbc53fbe-68cf-454c-bd3a-e7aa5f5095ae,
  abstract     = {<p>Background: Coronary heart disease (CHD) risk inversely associates with levels of high-density lipoprotein cholesterol (HDL-C). The protective effect of HDL is thought to depend on its functionality, such as its ability to induce cholesterol efflux. Materials and methods: We compared plasma cholesterol efflux capacity between male familial hypercholesterolaemia (FH) patients with and without CHD relative to their non-FH brothers, and examined HDL constituents including sphingosine-1-phosphate (S1P) and its carrier apolipoprotein M (apoM). Results: Seven FH patients were asymptomatic and six had experienced a cardiac event at a mean age of 39 years. Compared to their non-FH brothers, cholesterol efflux from macrophages to plasma from the FH patients without CHD was 16 ± 22% (mean ± SD) higher and to plasma from the FH patients with CHD was 7 ± 8% lower (P = 0·03, CHD vs. non-CHD). Compared to their non-FH brothers, FH patients without CHD displayed significantly higher levels of HDL-cholesterol, HDL-S1P and apoM, while FH patients with CHD displayed lower levels than their non-FH brothers. Conclusions: A higher plasma cholesterol efflux capacity and higher S1P and apoM content of HDL in asymptomatic FH patients may play a role in their apparent protection from premature CHD.</p>},
  author       = {Versmissen, Jorie and Vongpromek, Ranitha and Yahya, Reyhana and van der Net, Jeroen B. and van Vark-van der Zee, Leonie and Blommesteijn-Touw, Jeannette and Wattimena, Darcos and Rietveld, Trinet and Pullinger, Clive R. and Christoffersen, Christina and Dahlbäck, Björn and Kane, John P. and Mulder, Monique and Sijbrands, Eric J G},
  issn         = {0014-2972},
  keyword      = {Apolipoprotein M,cholesterol efflux,familial hypercholesterolaemia,high-density lipoprotein,sphingolipids,sphingosine-phosphate},
  language     = {eng},
  month        = {07},
  number       = {7},
  pages        = {643--650},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Clinical Investigation},
  title        = {Familial hypercholesterolaemia : cholesterol efflux and coronary disease},
  url          = {http://dx.doi.org/10.1111/eci.12643},
  volume       = {46},
  year         = {2016},
}