Enhanced distribution kinetics in liquid-liquid extraction by CO2-expanded solvents
Cunico, Larissa P. LU ; Sun, Mingzhe LU ; Rui, Yu ; Ghirmai, Semhar ; Enekvist, Markus ; Lundegard, Simon ; Sandahl, Margareta LU and Turner, Charlotta LU
(2020)
In Journal of Supercritical Fluids
163.
- Abstract
Liquid-liquid extraction (LLE) is a useful extraction technique for highly complex samples, however, it suffers from being slow due to mass transfer limitations. Carbon dioxide expanded liquids (CXL) is a good replacement of traditional organic solvents for extraction, and for the first time, the use of CXL in LLE was evaluated. An equipment consisting of a high-pressure view cell with on-line gas chromatography analysis was built and validated, and thereafter used to obtain novel phase equilibria data of the CO2/n-octanol/water system. The system was connected on-line to HPLC to study the potential of CO2-expanded liquid-liquid extraction (CXLLE) of pharmaceutical contaminants in water. In comparison with... (More)
Liquid-liquid extraction (LLE) is a useful extraction technique for highly complex samples, however, it suffers from being slow due to mass transfer limitations. Carbon dioxide expanded liquids (CXL) is a good replacement of traditional organic solvents for extraction, and for the first time, the use of CXL in LLE was evaluated. An equipment consisting of a high-pressure view cell with on-line gas chromatography analysis was built and validated, and thereafter used to obtain novel phase equilibria data of the CO2/n-octanol/water system. The system was connected on-line to HPLC to study the potential of CO2-expanded liquid-liquid extraction (CXLLE) of pharmaceutical contaminants in water. In comparison with traditional LLE performed under similar experimental conditions, the addition of CO2 as a viscosity-lowering entrainer significantly increased the speed of mass transfer. Changes in compound log D (octanol-water distribution ratio) values brought by the CO2 expansion also proved the possibility of selectivity-tuning in CXLLE.
(Less)
- author
- Cunico, Larissa P.
LU
; Sun, Mingzhe
LU
; Rui, Yu
; Ghirmai, Semhar
; Enekvist, Markus
; Lundegard, Simon
; Sandahl, Margareta
LU
and Turner, Charlotta
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CO-expandend solvents, Distribution kinetics, liquid-liquid extraction, phase equilibria
- in
- Journal of Supercritical Fluids
- volume
- 163
- article number
- 104874
- publisher
- Elsevier
- external identifiers
-
- scopus:85084433986
- ISSN
- 0896-8446
- DOI
- 10.1016/j.supflu.2020.104874
- language
- English
- LU publication?
- yes
- id
- dc1bc89e-98b2-499e-9461-2f99e85beb30
- date added to LUP
- 2020-06-01 12:36:42
- date last changed
- 2025-04-04 14:26:43
@article{dc1bc89e-98b2-499e-9461-2f99e85beb30,
abstract = {{<p>Liquid-liquid extraction (LLE) is a useful extraction technique for highly complex samples, however, it suffers from being slow due to mass transfer limitations. Carbon dioxide expanded liquids (CXL) is a good replacement of traditional organic solvents for extraction, and for the first time, the use of CXL in LLE was evaluated. An equipment consisting of a high-pressure view cell with on-line gas chromatography analysis was built and validated, and thereafter used to obtain novel phase equilibria data of the CO<sub>2</sub>/n-octanol/water system. The system was connected on-line to HPLC to study the potential of CO<sub>2</sub>-expanded liquid-liquid extraction (CXLLE) of pharmaceutical contaminants in water. In comparison with traditional LLE performed under similar experimental conditions, the addition of CO<sub>2</sub> as a viscosity-lowering entrainer significantly increased the speed of mass transfer. Changes in compound log D (octanol-water distribution ratio) values brought by the CO<sub>2</sub> expansion also proved the possibility of selectivity-tuning in CXLLE.</p>}},
author = {{Cunico, Larissa P. and Sun, Mingzhe and Rui, Yu and Ghirmai, Semhar and Enekvist, Markus and Lundegard, Simon and Sandahl, Margareta and Turner, Charlotta}},
issn = {{0896-8446}},
keywords = {{CO-expandend solvents; Distribution kinetics; liquid-liquid extraction; phase equilibria}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Journal of Supercritical Fluids}},
title = {{Enhanced distribution kinetics in liquid-liquid extraction by CO<sub>2</sub>-expanded solvents}},
url = {{http://dx.doi.org/10.1016/j.supflu.2020.104874}},
doi = {{10.1016/j.supflu.2020.104874}},
volume = {{163}},
year = {{2020}},
}