Advanced

Familial risk for histology-specific bone cancers : An updated study in Sweden

Ji, Jianguang LU and Hemminki, Kari LU (2006) In European Journal of Cancer 42(14). p.2343-2349
Abstract

We used the nation-wide Swedish Family-Cancer Database to examine the familial risks of histology-specific bone cancers in offspring by parental or sibling probands. Adjusted standardised incidence ratios (SIRs) were used to measure the risk. Among the 1327 offspring bone cancers, only two parent-offspring pairs and one sibling pair were noted with concordant bone cancer but the SIRs were not significant. Significant associations were observed in specific histological types or specific age groups, some of which may be chance findings arising from multiple comparisons. However, the risk of early-onset (<25 years) osteosarcoma in offspring was significantly increased when mothers presented with breast cancer (1.7) and melanoma (2.9),... (More)

We used the nation-wide Swedish Family-Cancer Database to examine the familial risks of histology-specific bone cancers in offspring by parental or sibling probands. Adjusted standardised incidence ratios (SIRs) were used to measure the risk. Among the 1327 offspring bone cancers, only two parent-offspring pairs and one sibling pair were noted with concordant bone cancer but the SIRs were not significant. Significant associations were observed in specific histological types or specific age groups, some of which may be chance findings arising from multiple comparisons. However, the risk of early-onset (<25 years) osteosarcoma in offspring was significantly increased when mothers presented with breast cancer (1.7) and melanoma (2.9), suggesting that Li-Fraumeni syndrome could partly explain this familial aggregation. Other associations, such as childhood osteosarcoma with parental liver cancer, Ewing's sarcoma with kidney cancer and giant cell sarcoma with maternal breast cancer, were novel findings and may be related to other familial diseases.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Bone cancer, Chondrosarcoma, Ewing's sarcoma, Familial risk, Giant cell sarcoma, Osteosarcoma
in
European Journal of Cancer
volume
42
issue
14
pages
7 pages
publisher
IFAC & Elsevier Ltd.
external identifiers
  • scopus:33748114339
ISSN
0959-8049
DOI
10.1016/j.ejca.2005.11.043
language
English
LU publication?
no
id
dc808e7c-ad83-4c78-ab57-fb741be605b3
date added to LUP
2019-01-30 10:45:53
date last changed
2019-06-11 04:00:27
@article{dc808e7c-ad83-4c78-ab57-fb741be605b3,
  abstract     = {<p>We used the nation-wide Swedish Family-Cancer Database to examine the familial risks of histology-specific bone cancers in offspring by parental or sibling probands. Adjusted standardised incidence ratios (SIRs) were used to measure the risk. Among the 1327 offspring bone cancers, only two parent-offspring pairs and one sibling pair were noted with concordant bone cancer but the SIRs were not significant. Significant associations were observed in specific histological types or specific age groups, some of which may be chance findings arising from multiple comparisons. However, the risk of early-onset (&lt;25 years) osteosarcoma in offspring was significantly increased when mothers presented with breast cancer (1.7) and melanoma (2.9), suggesting that Li-Fraumeni syndrome could partly explain this familial aggregation. Other associations, such as childhood osteosarcoma with parental liver cancer, Ewing's sarcoma with kidney cancer and giant cell sarcoma with maternal breast cancer, were novel findings and may be related to other familial diseases.</p>},
  author       = {Ji, Jianguang and Hemminki, Kari},
  issn         = {0959-8049},
  keyword      = {Bone cancer,Chondrosarcoma,Ewing's sarcoma,Familial risk,Giant cell sarcoma,Osteosarcoma},
  language     = {eng},
  month        = {09},
  number       = {14},
  pages        = {2343--2349},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Familial risk for histology-specific bone cancers : An updated study in Sweden},
  url          = {http://dx.doi.org/10.1016/j.ejca.2005.11.043},
  volume       = {42},
  year         = {2006},
}