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Aged garlic extract reduces IL-6 : A double-blind placebo-controlled trial in females with a low risk of cardiovascular disease

Wlosinska, Martiné LU ; Nilsson, Ann Christin LU ; Hlebowicz, Joanna LU ; Fakhro, Mohammed LU ; Malmsjö, Malin LU and Lindstedt, Sandra LU (2021) In Evidence-based Complementary and Alternative Medicine 2021.
Abstract

Background. Chronic inflammation is a risk factor for cardiovascular disease. The aim of the study was to evaluate whether a daily supplementation of aged garlic extract (AGE) could reduce inflammation in females with low risk for cardiovascular disease. The study was conducted at a single center, as a parallel randomized placebo-controlled trial. Method. 63 females with a Framingham risk score over 10 underwent cardiac computed tomography (CT) scan. Of those, patients with a coronary artery calcium (CAC) scores less than 5 (n = 31) met the inclusion criteria and were randomized, in a double-blind manner to an intake of placebo or AGE (2400 mg daily) for 1 year. Results. Main outcome measure was changes in inflammatory biomarkers, blood... (More)

Background. Chronic inflammation is a risk factor for cardiovascular disease. The aim of the study was to evaluate whether a daily supplementation of aged garlic extract (AGE) could reduce inflammation in females with low risk for cardiovascular disease. The study was conducted at a single center, as a parallel randomized placebo-controlled trial. Method. 63 females with a Framingham risk score over 10 underwent cardiac computed tomography (CT) scan. Of those, patients with a coronary artery calcium (CAC) scores less than 5 (n = 31) met the inclusion criteria and were randomized, in a double-blind manner to an intake of placebo or AGE (2400 mg daily) for 1 year. Results. Main outcome measure was changes in inflammatory biomarkers, blood pressure, fastening blood glucose, and blood lipids. A total of 29 patients (14 in the AGE group and 15 in the placebo group) completed the study and were analyzed. Females treated with AGE showed lower levels of inflammatory marker IL-6 after 12 months of treatment compared to females receiving placebo (p < 0.05). The blood lipids had a trend towards a lowering effect in females treated with AGE; however, this trend was not significant. Conclusion. The present study concludes that AGE lowers IL-6 in females with a risk profile of cardiovascular disease. We could also conclude that risk prediction with cardiac CT scan turned out to be superior in estimating the risk of cardiac disease compared to Framingham risk score.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Evidence-based Complementary and Alternative Medicine
volume
2021
article number
6636875
publisher
Hindawi Limited
external identifiers
  • pmid:33868439
  • scopus:85104803625
ISSN
1741-427X
DOI
10.1155/2021/6636875
project
Microvascular blood flow measurements with laser speckle contranst imaging in skin, lung and heart
language
English
LU publication?
yes
id
dcd513e4-5bdd-4e49-b408-ecb1b4c643e7
date added to LUP
2021-05-11 15:46:05
date last changed
2024-06-15 11:03:23
@article{dcd513e4-5bdd-4e49-b408-ecb1b4c643e7,
  abstract     = {{<p>Background. Chronic inflammation is a risk factor for cardiovascular disease. The aim of the study was to evaluate whether a daily supplementation of aged garlic extract (AGE) could reduce inflammation in females with low risk for cardiovascular disease. The study was conducted at a single center, as a parallel randomized placebo-controlled trial. Method. 63 females with a Framingham risk score over 10 underwent cardiac computed tomography (CT) scan. Of those, patients with a coronary artery calcium (CAC) scores less than 5 (n = 31) met the inclusion criteria and were randomized, in a double-blind manner to an intake of placebo or AGE (2400 mg daily) for 1 year. Results. Main outcome measure was changes in inflammatory biomarkers, blood pressure, fastening blood glucose, and blood lipids. A total of 29 patients (14 in the AGE group and 15 in the placebo group) completed the study and were analyzed. Females treated with AGE showed lower levels of inflammatory marker IL-6 after 12 months of treatment compared to females receiving placebo (p &lt; 0.05). The blood lipids had a trend towards a lowering effect in females treated with AGE; however, this trend was not significant. Conclusion. The present study concludes that AGE lowers IL-6 in females with a risk profile of cardiovascular disease. We could also conclude that risk prediction with cardiac CT scan turned out to be superior in estimating the risk of cardiac disease compared to Framingham risk score. </p>}},
  author       = {{Wlosinska, Martiné and Nilsson, Ann Christin and Hlebowicz, Joanna and Fakhro, Mohammed and Malmsjö, Malin and Lindstedt, Sandra}},
  issn         = {{1741-427X}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{Evidence-based Complementary and Alternative Medicine}},
  title        = {{Aged garlic extract reduces IL-6 : A double-blind placebo-controlled trial in females with a low risk of cardiovascular disease}},
  url          = {{http://dx.doi.org/10.1155/2021/6636875}},
  doi          = {{10.1155/2021/6636875}},
  volume       = {{2021}},
  year         = {{2021}},
}