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Disassembly of Dipeptide Single Crystals Can Transform the Lipid Membrane into a Network

Fu, Meifang ; Li, Qi ; Sun, Bingbing ; Yang, Yang LU ; Dai, Luru ; Nylander, Tommy LU and Li, Junbai (2017) In ACS Nano 11(7). p.7349-7354
Abstract

Coupling between cytoskeleton and membranes is critical to cell movement as well as organelle formation. Here, we demonstrate that self-assembled single crystals of a dipeptide, diphenylalanine (FF), can interact with liposomes to form cytoskeleton-like structures. Under a physiological condition, disassembly of FF crystals deforms and translocates supported lipid membrane. The system exhibits similar dynamic characteristics to the endoplasmic reticulum (ER) network in cells. This bottom-up system thus indicates that external matter can participate in the deformation of liposomes, and disassembly of the nanostructures enables a system with distinct dynamic behaviors.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biomimetic, membranes, peptides, phospholipids, self-assembly
in
ACS Nano
volume
11
issue
7
pages
6 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:28657720
  • wos:000406649700083
  • scopus:85026300151
ISSN
1936-0851
DOI
10.1021/acsnano.7b03468
language
English
LU publication?
yes
id
dd298d28-8a4f-49c9-9159-4a999a29f248
date added to LUP
2017-08-31 13:12:53
date last changed
2024-04-14 16:43:40
@article{dd298d28-8a4f-49c9-9159-4a999a29f248,
  abstract     = {{<p>Coupling between cytoskeleton and membranes is critical to cell movement as well as organelle formation. Here, we demonstrate that self-assembled single crystals of a dipeptide, diphenylalanine (FF), can interact with liposomes to form cytoskeleton-like structures. Under a physiological condition, disassembly of FF crystals deforms and translocates supported lipid membrane. The system exhibits similar dynamic characteristics to the endoplasmic reticulum (ER) network in cells. This bottom-up system thus indicates that external matter can participate in the deformation of liposomes, and disassembly of the nanostructures enables a system with distinct dynamic behaviors.</p>}},
  author       = {{Fu, Meifang and Li, Qi and Sun, Bingbing and Yang, Yang and Dai, Luru and Nylander, Tommy and Li, Junbai}},
  issn         = {{1936-0851}},
  keywords     = {{biomimetic; membranes; peptides; phospholipids; self-assembly}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{7349--7354}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{ACS Nano}},
  title        = {{Disassembly of Dipeptide Single Crystals Can Transform the Lipid Membrane into a Network}},
  url          = {{http://dx.doi.org/10.1021/acsnano.7b03468}},
  doi          = {{10.1021/acsnano.7b03468}},
  volume       = {{11}},
  year         = {{2017}},
}