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Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.

Jerkeman, Mats LU ; Aman, P ; Cavallin-Ståhl, Eva LU ; Torlakovic, E ; Åkerman, Måns LU ; Mitelman, Felix LU orcid and Fioretos, Thoas LU (2002) In International Journal of Oncology 20(1). p.161-165
Abstract
The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase... (More)
The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase (LDH), and a higher patient age. No association between BCL6 status and expression of BCL2, Ki-67 or TP53 was found. Patients presenting with BCL6 rearrangement displayed a weak trend towards better overall and failure-free survival (67 and 67% at 5 years), compared to patients with germline BCL6 (63 and 52%), but the difference was not statistically significant. In accordance with previously published series, the presence of BCL6 rearrangement does not define a prognostically distinct subgroup of DLBCL. Assessment of BCL6 status may, however, be of clinical interest when related to other prognostic variables. (Less)
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organization
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Contribution to journal
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published
subject
keywords
Gene Rearrangement B-Lymphocyte : genetics, Human, Immunophenotyping, Lymphoma B-Cell : drug therapy : genetics, Leucovorin : therapeutic use, Lactate Dehydrogenase : metabolism, Lymphoma Large-Cell Diffuse : drug therapy : genetics, Male, Methotrexate : therapeutic use, Middle Age, Neoplasm Staging, Prednisone : therapeutic use, Prognosis, Proto-Oncogene Proteins : genetics, Support Non-U.S. Gov't, Vincristine : therapeutic use, Transcription Factors : genetics, Doxorubicin : therapeutic use, DNA-Binding Proteins : genetics, DNA Neoplasm : analysis : metabolism, Cyclophosphamide : therapeutic use, Blotting Southern, Bleomycin : therapeutic use, Antineoplastic Combined Chemotherapy Protocols : therapeutic use, Aged, Adolescence, Adult
in
International Journal of Oncology
volume
20
issue
1
pages
161 - 165
publisher
Spandidos Publications
external identifiers
  • wos:000172916500023
  • pmid:11743658
  • scopus:0036133890
ISSN
1019-6439
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Division of Clinical Genetics (013022003), Oncology, MV (013035000)
id
dd3c1cf3-397d-4d51-9756-a22b261e6272 (old id 107004)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11743658
http://147.52.72.117/IJO/2002/volume20/number1/161-165.pdf
date added to LUP
2016-04-01 15:36:42
date last changed
2022-05-08 04:32:18
@article{dd3c1cf3-397d-4d51-9756-a22b261e6272,
  abstract     = {{The purpose of this study was to investigate the prognostic implications of BCL6 rearrangement in a uniformly treated population of patients with diffuse large B-cell lymphoma (DLBCL) and to characterise the relationship between BCL6 rearrangement and prognostic factors. A total of 269 patients with DLBCL entered a randomised trial comparing the chemotherapy regimen CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) to the MACOP-B (methotrexate, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) regimen. In 44 cases, frozen tissue was available for assessment of BCL6 status by Southern blot analysis. BCL6 was rearranged in six of 43 evaluable cases (14%), and was associated with elevated lactate dehydrogenase (LDH), and a higher patient age. No association between BCL6 status and expression of BCL2, Ki-67 or TP53 was found. Patients presenting with BCL6 rearrangement displayed a weak trend towards better overall and failure-free survival (67 and 67% at 5 years), compared to patients with germline BCL6 (63 and 52%), but the difference was not statistically significant. In accordance with previously published series, the presence of BCL6 rearrangement does not define a prognostically distinct subgroup of DLBCL. Assessment of BCL6 status may, however, be of clinical interest when related to other prognostic variables.}},
  author       = {{Jerkeman, Mats and Aman, P and Cavallin-Ståhl, Eva and Torlakovic, E and Åkerman, Måns and Mitelman, Felix and Fioretos, Thoas}},
  issn         = {{1019-6439}},
  keywords     = {{Gene Rearrangement B-Lymphocyte : genetics; Human; Immunophenotyping; Lymphoma B-Cell : drug therapy : genetics; Leucovorin : therapeutic use; Lactate Dehydrogenase : metabolism; Lymphoma Large-Cell Diffuse : drug therapy : genetics; Male; Methotrexate : therapeutic use; Middle Age; Neoplasm Staging; Prednisone : therapeutic use; Prognosis; Proto-Oncogene Proteins : genetics; Support Non-U.S. Gov't; Vincristine : therapeutic use; Transcription Factors : genetics; Doxorubicin : therapeutic use; DNA-Binding Proteins : genetics; DNA Neoplasm : analysis : metabolism; Cyclophosphamide : therapeutic use; Blotting Southern; Bleomycin : therapeutic use; Antineoplastic Combined Chemotherapy Protocols : therapeutic use; Aged; Adolescence; Adult}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{161--165}},
  publisher    = {{Spandidos Publications}},
  series       = {{International Journal of Oncology}},
  title        = {{Prognostic implications of BCL6 rearrangement in uniformly treated patients with diffuse large B-cell lymphoma--a Nordic Lymphoma Group study.}},
  url          = {{http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11743658}},
  volume       = {{20}},
  year         = {{2002}},
}