Minimal invasive LASER-resection vs. radiotherapy as primary treatment of early glottic cancer. A population-based study with, up to 16 years follow up of survival, rate of laryngectomy and voice function
(2024) In Acta Oto-Laryngologica p.1-7- Abstract
BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.
OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.
METHOD: A total of 268 patients with previously untreated T1-T2 glottic carcinoma were studied. They were primarily treated with either radiotherapy (n = 119) or laser resection (n = 149). Survival, need for additional treatment (radiotherapy and/or total layngectomi) and voice function was compared.
RESULT: Median follow up time was 7 years with range 0.5-16.6. There was no... (More)
BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.
OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.
METHOD: A total of 268 patients with previously untreated T1-T2 glottic carcinoma were studied. They were primarily treated with either radiotherapy (n = 119) or laser resection (n = 149). Survival, need for additional treatment (radiotherapy and/or total layngectomi) and voice function was compared.
RESULT: Median follow up time was 7 years with range 0.5-16.6. There was no difference in the overall survival (p = .065) or disease-specific survival. (p = .126). After radiotherapy 32/119 patients and after laser resection 57/149 patients had recurrence. Total rate of laryngectomy was 24% in the radiotherapy group, and 8% in the laser resection group (p = .001). Voice analysis (T1A) showed more roughness in the radiotherapy group, otherwise no difference.
CONCLUSIONS: By reducing the surgical margins, we have achieved a better voice function (T1A) but more patients have needed repeated laser excisions and some have also needed supplementary radiotherapy. The risk of laryngectomy and survival were apparently not affected.
(Less)
- author
- Rydell, Roland LU ; Andreasson, Josefine LU ; Gustafsson Baldwin, Sara and Clarhed, Nathalie
- organization
- publishing date
- 2024-01-31
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- Acta Oto-Laryngologica
- pages
- 1 - 7
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85184185030
- pmid:38294703
- ISSN
- 1651-2251
- DOI
- 10.1080/00016489.2023.2299674
- language
- English
- LU publication?
- yes
- id
- dd4101ce-7f5b-4636-8498-3506dd2421eb
- date added to LUP
- 2024-02-25 19:11:59
- date last changed
- 2024-04-25 12:51:28
@article{dd4101ce-7f5b-4636-8498-3506dd2421eb,
abstract = {{<p>BACKGROUND: Early glottic cancer can be treated with laser resection or radiotherapy. In an earlier study, we found that voice function after laser resection was inferior to that after radiotherapy.</p><p>OBJECTIVES: This study was designed to determine if reduced margins at laser resection improved voice function without impairing oncologic results.</p><p>METHOD: A total of 268 patients with previously untreated T1-T2 glottic carcinoma were studied. They were primarily treated with either radiotherapy (n = 119) or laser resection (n = 149). Survival, need for additional treatment (radiotherapy and/or total layngectomi) and voice function was compared.</p><p>RESULT: Median follow up time was 7 years with range 0.5-16.6. There was no difference in the overall survival (p = .065) or disease-specific survival. (p = .126). After radiotherapy 32/119 patients and after laser resection 57/149 patients had recurrence. Total rate of laryngectomy was 24% in the radiotherapy group, and 8% in the laser resection group (p = .001). Voice analysis (T1A) showed more roughness in the radiotherapy group, otherwise no difference.</p><p>CONCLUSIONS: By reducing the surgical margins, we have achieved a better voice function (T1A) but more patients have needed repeated laser excisions and some have also needed supplementary radiotherapy. The risk of laryngectomy and survival were apparently not affected.</p>}},
author = {{Rydell, Roland and Andreasson, Josefine and Gustafsson Baldwin, Sara and Clarhed, Nathalie}},
issn = {{1651-2251}},
language = {{eng}},
month = {{01}},
pages = {{1--7}},
publisher = {{Taylor & Francis}},
series = {{Acta Oto-Laryngologica}},
title = {{Minimal invasive LASER-resection vs. radiotherapy as primary treatment of early glottic cancer. A population-based study with, up to 16 years follow up of survival, rate of laryngectomy and voice function}},
url = {{http://dx.doi.org/10.1080/00016489.2023.2299674}},
doi = {{10.1080/00016489.2023.2299674}},
year = {{2024}},
}