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Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI

Huang, Jianpan ; van Zijl, Peter C M ; Han, Xiongqi ; Dong, Celia M ; Cheng, Gerald W Y ; Tse, Kai-Hei ; Knutsson, Linda LU orcid ; Chen, Lin ; Lai, Joseph H C and Wu, Ed X , et al. (2020) In Science Advances 6(20).
Abstract

Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI... (More)

Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science Advances
volume
6
issue
20
article number
eaba3884
publisher
American Association for the Advancement of Science (AAAS)
external identifiers
  • scopus:85084787075
  • pmid:32426510
ISSN
2375-2548
DOI
10.1126/sciadv.aba3884
project
Natural sugar as an MRI contrast agent for cancer diagnosis
language
English
LU publication?
yes
id
ddb83ddc-54c8-4cd8-ace6-3e9617f3d1f3
date added to LUP
2020-05-28 21:05:46
date last changed
2024-05-15 11:31:59
@article{ddb83ddc-54c8-4cd8-ace6-3e9617f3d1f3,
  abstract     = {{<p>Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.</p>}},
  author       = {{Huang, Jianpan and van Zijl, Peter C M and Han, Xiongqi and Dong, Celia M and Cheng, Gerald W Y and Tse, Kai-Hei and Knutsson, Linda and Chen, Lin and Lai, Joseph H C and Wu, Ed X and Xu, Jiadi and Chan, Kannie W Y}},
  issn         = {{2375-2548}},
  language     = {{eng}},
  number       = {{20}},
  publisher    = {{American Association for the Advancement of Science (AAAS)}},
  series       = {{Science Advances}},
  title        = {{Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI}},
  url          = {{http://dx.doi.org/10.1126/sciadv.aba3884}},
  doi          = {{10.1126/sciadv.aba3884}},
  volume       = {{6}},
  year         = {{2020}},
}