Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI
(2020) In Science Advances 6(20).- Abstract
Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI... (More)
Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.
(Less)
- author
- organization
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science Advances
- volume
- 6
- issue
- 20
- article number
- eaba3884
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- pmid:32426510
- scopus:85084787075
- ISSN
- 2375-2548
- DOI
- 10.1126/sciadv.aba3884
- project
- Natural sugar as an MRI contrast agent for cancer diagnosis
- language
- English
- LU publication?
- yes
- id
- ddb83ddc-54c8-4cd8-ace6-3e9617f3d1f3
- date added to LUP
- 2020-05-28 21:05:46
- date last changed
- 2024-09-18 23:27:26
@article{ddb83ddc-54c8-4cd8-ace6-3e9617f3d1f3, abstract = {{<p>Altered cerebral glucose uptake is one of the hallmarks of Alzheimer's disease (AD). A dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) approach was developed to simultaneously monitor d-glucose uptake and clearance in both brain parenchyma and cerebrospinal fluid (CSF). We observed substantially higher uptake in parenchyma of young (6 months) transgenic AD mice compared to age-matched wild-type (WT) mice. Notably lower uptakes were observed in parenchyma and CSF of old (16 months) AD mice. Both young and old AD mice had an obviously slower CSF clearance than age-matched WT mice. This resembles recent reports of the hampered CSF clearance that leads to protein accumulation in the brain. These findings suggest that DGE MRI can identify altered glucose uptake and clearance in young AD mice upon the emergence of amyloid plaques. DGE MRI of brain parenchyma and CSF has potential for early AD stratification, especially at 3T clinical field strength MRI.</p>}}, author = {{Huang, Jianpan and van Zijl, Peter C M and Han, Xiongqi and Dong, Celia M and Cheng, Gerald W Y and Tse, Kai-Hei and Knutsson, Linda and Chen, Lin and Lai, Joseph H C and Wu, Ed X and Xu, Jiadi and Chan, Kannie W Y}}, issn = {{2375-2548}}, language = {{eng}}, number = {{20}}, publisher = {{American Association for the Advancement of Science (AAAS)}}, series = {{Science Advances}}, title = {{Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer's disease detected by dynamic glucose-enhanced MRI}}, url = {{http://dx.doi.org/10.1126/sciadv.aba3884}}, doi = {{10.1126/sciadv.aba3884}}, volume = {{6}}, year = {{2020}}, }