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Arterial spin-labeling in children with brain tumor : A meta-analysis

Delgado, A. F. ; De Luca, F. ; Hanagandi, P. and Van Westen, D. LU orcid (2018) In American Journal of Neuroradiology 39(8). p.1543-1549
Abstract

BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS: Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS: Data... (More)

BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS: Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS: Data were aggregated using the bivariate summary receiver operating characteristic curve model. Heterogeneity was explored with meta-regression and subgroup analyses. The study protocol was published at PROSPERO (CRD42017075055). Eight studies encompassing 286 pediatric patients were included. The mean differences in absolute CBF were 29.62 mL/min/100 g (95% CI, 10.43- 48.82 mL/min/100 g), I2 74, P .002, and 1.34 mL/min/100 g (95% CI, 0.95-1.74 mL/min/100 g), P .001, I2 38 for relative CBF. Pooled sensitivity for relative CBF ranged from 0.75 to 0.90, and specificity, from 0.77 to 0.92 with an area under curve 0.92. Meta-regression showed no moderating effect of sequence parameters TE, TR, acquisition time, or ROI method. LIMITATIONS: Included tumor types, analysis method, and original data varied among included studies. CONCLUSIONS: Arterial spin-labeling- derived CBF measures showed high diagnostic accuracy for discriminating low- and high-grade tumors in pediatric patients with brain tumors. The relative CBF showed less variation among studies than the absolute CBF.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
American Journal of Neuroradiology
volume
39
issue
8
pages
7 pages
publisher
American Society of Neuroradiology
external identifiers
  • pmid:30072368
  • scopus:85051441753
ISSN
0195-6108
DOI
10.3174/ajnr.A5727
language
English
LU publication?
yes
id
ddeb619e-83db-4791-80b5-3e26c7b56327
date added to LUP
2018-09-11 08:34:41
date last changed
2024-07-08 18:31:32
@article{ddeb619e-83db-4791-80b5-3e26c7b56327,
  abstract     = {{<p>BACKGROUND: The value of arterial spin-labeling in a pediatric population has not been assessed in a meta-analysis. PURPOSE: Our aim was to assess the diagnostic accuracy of arterial spin-labeling- derived cerebral blood flow to discriminate low- and high-grade tumors. DATA SOURCES: MEDLINE, EMBASE, the Web of Science Core Collection, and the Cochrane Library were used. STUDY SELECTION: Pediatric patients with arterial spin-labeling MR imaging with verified neuropathologic diagnoses were included. DATA ANALYSIS: Relative CBF and absolute CBF and tumor grade were extracted, including sequence-specific information. Mean differences in CBF between low- and high-grade tumors were calculated. Study quality was assessed. DATA SYNTHESIS: Data were aggregated using the bivariate summary receiver operating characteristic curve model. Heterogeneity was explored with meta-regression and subgroup analyses. The study protocol was published at PROSPERO (CRD42017075055). Eight studies encompassing 286 pediatric patients were included. The mean differences in absolute CBF were 29.62 mL/min/100 g (95% CI, 10.43- 48.82 mL/min/100 g), I<sup>2</sup> 74, P .002, and 1.34 mL/min/100 g (95% CI, 0.95-1.74 mL/min/100 g), P .001, I<sup>2</sup> 38 for relative CBF. Pooled sensitivity for relative CBF ranged from 0.75 to 0.90, and specificity, from 0.77 to 0.92 with an area under curve 0.92. Meta-regression showed no moderating effect of sequence parameters TE, TR, acquisition time, or ROI method. LIMITATIONS: Included tumor types, analysis method, and original data varied among included studies. CONCLUSIONS: Arterial spin-labeling- derived CBF measures showed high diagnostic accuracy for discriminating low- and high-grade tumors in pediatric patients with brain tumors. The relative CBF showed less variation among studies than the absolute CBF.</p>}},
  author       = {{Delgado, A. F. and De Luca, F. and Hanagandi, P. and Van Westen, D.}},
  issn         = {{0195-6108}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{1543--1549}},
  publisher    = {{American Society of Neuroradiology}},
  series       = {{American Journal of Neuroradiology}},
  title        = {{Arterial spin-labeling in children with brain tumor : A meta-analysis}},
  url          = {{http://dx.doi.org/10.3174/ajnr.A5727}},
  doi          = {{10.3174/ajnr.A5727}},
  volume       = {{39}},
  year         = {{2018}},
}