The impact of diabetes mellitus on major amputation among patients with chronic limb threatening ischemia undergoing elective endovascular therapy- a nationwide propensity score adjusted analysis
(2021) In Journal of Diabetes and its Complications 35(2).- Abstract
Aim: To investigate the risk of major amputation after elective endovascular therapy in patients with chronic limb threatening ischemia (CLTI) comparing patients with and without diabetes mellitus (DM). Methods: In this nationwide cohort study, all patients registered in the Swedish Vascular Register after elective endovascular therapy for CLTI caused by infra-inguinal arterial disease from 2010 to 2014 were included. Among 4578 individuals, 2251 had DM and were registered in the National Diabetes Register between 2009 and 2014. A propensity score adjusted Cox regression analysis was conducted to compare outcomes between groups. Median follow-up was 4.0 and 3.6 years for patients with DM and without DM, respectively. Results: The... (More)
Aim: To investigate the risk of major amputation after elective endovascular therapy in patients with chronic limb threatening ischemia (CLTI) comparing patients with and without diabetes mellitus (DM). Methods: In this nationwide cohort study, all patients registered in the Swedish Vascular Register after elective endovascular therapy for CLTI caused by infra-inguinal arterial disease from 2010 to 2014 were included. Among 4578 individuals, 2251 had DM and were registered in the National Diabetes Register between 2009 and 2014. A propensity score adjusted Cox regression analysis was conducted to compare outcomes between groups. Median follow-up was 4.0 and 3.6 years for patients with DM and without DM, respectively. Results: The incidence rates of major amputation and acute myocardial infarction (AMI) were 43% (95% CI 1.23–1.67) and 37% (95% CI 1.13–1.67) higher, respectively, among patients with DM compared to patients without DM. There was no difference in mortality (HR 1.04, 95% CI 0.95–1.14). Conclusions: Patients with DM had a higher risk of major amputation and AMI compared to those without DM after elective endovascular therapy for CLTI. Prevention of DM with CLTI is of utmost importance to reduce the risk of adverse limb and cardiovascular outcomes.
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- author
- Lilja, Erika LU ; Gottsäter, Anders LU ; Miftaraj, Mervete ; Ekelund, Jan ; Eliasson, Björn ; Svensson, Ann Marie ; Zarrouk, Moncef LU ; Nilsson, Peter LU and Acosta, Stefan LU
- organization
- publishing date
- 2021-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chronic limb-threatening ischemia, Diabetes mellitus, Endovascular revascularization, Major amputation, Propensity score adjusted analysis
- in
- Journal of Diabetes and its Complications
- volume
- 35
- issue
- 2
- article number
- 107675
- publisher
- Elsevier
- external identifiers
-
- pmid:32828647
- scopus:85089584825
- ISSN
- 1056-8727
- DOI
- 10.1016/j.jdiacomp.2020.107675
- language
- English
- LU publication?
- yes
- id
- de390431-d644-4e2a-af05-bb5f9f543f0e
- date added to LUP
- 2020-08-28 10:29:09
- date last changed
- 2024-09-19 05:07:53
@article{de390431-d644-4e2a-af05-bb5f9f543f0e, abstract = {{<p>Aim: To investigate the risk of major amputation after elective endovascular therapy in patients with chronic limb threatening ischemia (CLTI) comparing patients with and without diabetes mellitus (DM). Methods: In this nationwide cohort study, all patients registered in the Swedish Vascular Register after elective endovascular therapy for CLTI caused by infra-inguinal arterial disease from 2010 to 2014 were included. Among 4578 individuals, 2251 had DM and were registered in the National Diabetes Register between 2009 and 2014. A propensity score adjusted Cox regression analysis was conducted to compare outcomes between groups. Median follow-up was 4.0 and 3.6 years for patients with DM and without DM, respectively. Results: The incidence rates of major amputation and acute myocardial infarction (AMI) were 43% (95% CI 1.23–1.67) and 37% (95% CI 1.13–1.67) higher, respectively, among patients with DM compared to patients without DM. There was no difference in mortality (HR 1.04, 95% CI 0.95–1.14). Conclusions: Patients with DM had a higher risk of major amputation and AMI compared to those without DM after elective endovascular therapy for CLTI. Prevention of DM with CLTI is of utmost importance to reduce the risk of adverse limb and cardiovascular outcomes.</p>}}, author = {{Lilja, Erika and Gottsäter, Anders and Miftaraj, Mervete and Ekelund, Jan and Eliasson, Björn and Svensson, Ann Marie and Zarrouk, Moncef and Nilsson, Peter and Acosta, Stefan}}, issn = {{1056-8727}}, keywords = {{Chronic limb-threatening ischemia; Diabetes mellitus; Endovascular revascularization; Major amputation; Propensity score adjusted analysis}}, language = {{eng}}, number = {{2}}, publisher = {{Elsevier}}, series = {{Journal of Diabetes and its Complications}}, title = {{The impact of diabetes mellitus on major amputation among patients with chronic limb threatening ischemia undergoing elective endovascular therapy- a nationwide propensity score adjusted analysis}}, url = {{http://dx.doi.org/10.1016/j.jdiacomp.2020.107675}}, doi = {{10.1016/j.jdiacomp.2020.107675}}, volume = {{35}}, year = {{2021}}, }