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Long-term rivastigmine treatment in a routine clinical setting.

Minthon, Lennart LU ; Wallin, Åsa LU ; Eriksson, Sture ; Wattmo, Carina LU and Andreasen, Niels (2009) In Acta Neurologica Scandinavica 119(3). p.180-185
Abstract
Objective - The aim of the study was to observe the effects of long-term rivastigmine treatment in patients with mild to moderate Alzheimer's disease (AD) in a routine clinical setting. Methods - This was a prospective, open-label, observational, multicentre, non-randomized study. Outcome measures included the Mini Mental State Examination (MMSE), the Clinician's Interview-Based Impression of Change (CIBIC) and the Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog). Results - Of 217 patients initiated into rivastigmine treatment, 62% (n = 135) remained on treatment for 24 months. Most patients droped out due to nursing home placement or side effects. Eighty per cent and 67% of completers exhibited a symptomatic... (More)
Objective - The aim of the study was to observe the effects of long-term rivastigmine treatment in patients with mild to moderate Alzheimer's disease (AD) in a routine clinical setting. Methods - This was a prospective, open-label, observational, multicentre, non-randomized study. Outcome measures included the Mini Mental State Examination (MMSE), the Clinician's Interview-Based Impression of Change (CIBIC) and the Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog). Results - Of 217 patients initiated into rivastigmine treatment, 62% (n = 135) remained on treatment for 24 months. Most patients droped out due to nursing home placement or side effects. Eighty per cent and 67% of completers exhibited a symptomatic attenuation of cognitive decline (</= 4-point deterioration) as assessed by using the MMSE and ADAS-cog respectively. Forty-four percent showed an unchanged/improved CIBIC rating. Conclusions - Over 60% of patients remained on treatment for 2 years in this routine clinical setting. In patients who remained on treatment, rivastigmine appeared to stabilize their condition and prevented or delayed symptomatic decline. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, rivastigmine, dementia.
in
Acta Neurologica Scandinavica
volume
119
issue
3
pages
180 - 185
publisher
Wiley-Blackwell
external identifiers
  • wos:000262949100006
  • pmid:18759798
  • scopus:59249086493
  • pmid:18759798
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2008.01086.x
language
English
LU publication?
yes
id
de71e466-e1ac-4aa2-b9e0-fe2813aa6b17 (old id 1243623)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18759798?dopt=Abstract
date added to LUP
2016-04-01 13:35:16
date last changed
2022-01-27 19:58:36
@article{de71e466-e1ac-4aa2-b9e0-fe2813aa6b17,
  abstract     = {{Objective - The aim of the study was to observe the effects of long-term rivastigmine treatment in patients with mild to moderate Alzheimer's disease (AD) in a routine clinical setting. Methods - This was a prospective, open-label, observational, multicentre, non-randomized study. Outcome measures included the Mini Mental State Examination (MMSE), the Clinician's Interview-Based Impression of Change (CIBIC) and the Alzheimer's Disease Assessment Scale - cognitive subscale (ADAS-cog). Results - Of 217 patients initiated into rivastigmine treatment, 62% (n = 135) remained on treatment for 24 months. Most patients droped out due to nursing home placement or side effects. Eighty per cent and 67% of completers exhibited a symptomatic attenuation of cognitive decline (&lt;/= 4-point deterioration) as assessed by using the MMSE and ADAS-cog respectively. Forty-four percent showed an unchanged/improved CIBIC rating. Conclusions - Over 60% of patients remained on treatment for 2 years in this routine clinical setting. In patients who remained on treatment, rivastigmine appeared to stabilize their condition and prevented or delayed symptomatic decline.}},
  author       = {{Minthon, Lennart and Wallin, Åsa and Eriksson, Sture and Wattmo, Carina and Andreasen, Niels}},
  issn         = {{1600-0404}},
  keywords     = {{Alzheimer's disease; rivastigmine; dementia.}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{180--185}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Neurologica Scandinavica}},
  title        = {{Long-term rivastigmine treatment in a routine clinical setting.}},
  url          = {{http://dx.doi.org/10.1111/j.1600-0404.2008.01086.x}},
  doi          = {{10.1111/j.1600-0404.2008.01086.x}},
  volume       = {{119}},
  year         = {{2009}},
}