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Structured evaluation of rodent behavioral tests used in drug discovery research

Hånell, Anders and Marklund, Niklas LU (2014) In Frontiers in Behavioral Neuroscience 8. p.1-13
Abstract

A large variety of rodent behavioral tests are currently being used to evaluate traits such as sensory-motor function, social interactions, anxiety-like and depressive-like behavior, substance dependence and various forms of cognitive function. Most behavioral tests have an inherent complexity, and their use requires consideration of several aspects such as the source of motivation in the test, the interaction between experimenter and animal, sources of variability, the sensory modality required by the animal to solve the task as well as costs and required work effort. Of particular importance is a test's validity because of its influence on the chance of successful translation of preclinical results to clinical settings. High validity... (More)

A large variety of rodent behavioral tests are currently being used to evaluate traits such as sensory-motor function, social interactions, anxiety-like and depressive-like behavior, substance dependence and various forms of cognitive function. Most behavioral tests have an inherent complexity, and their use requires consideration of several aspects such as the source of motivation in the test, the interaction between experimenter and animal, sources of variability, the sensory modality required by the animal to solve the task as well as costs and required work effort. Of particular importance is a test's validity because of its influence on the chance of successful translation of preclinical results to clinical settings. High validity may, however, have to be balanced against practical constraints and there are no behavioral tests with optimal characteristics. The design and development of new behavioral tests is therefore an ongoing effort and there are now well over one hundred tests described in the contemporary literature. Some of them are well established following extensive use, while others are novel and still unproven. The task of choosing a behavioral test for a particular project may therefore be daunting and the aim of the present review is to provide a structured way to evaluate rodent behavioral tests aimed at drug discovery research.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article, Review
in
Frontiers in Behavioral Neuroscience
volume
8
pages
1 - 13
publisher
Frontiers
external identifiers
  • scopus:84904692829
ISSN
1662-5153
DOI
10.3389/fnbeh.2014.00252
language
English
LU publication?
no
id
de7eb4e8-e0d3-4174-81d8-dc10ef4a9fd1
date added to LUP
2016-12-09 16:01:02
date last changed
2017-11-05 05:10:56
@article{de7eb4e8-e0d3-4174-81d8-dc10ef4a9fd1,
  abstract     = {<p>A large variety of rodent behavioral tests are currently being used to evaluate traits such as sensory-motor function, social interactions, anxiety-like and depressive-like behavior, substance dependence and various forms of cognitive function. Most behavioral tests have an inherent complexity, and their use requires consideration of several aspects such as the source of motivation in the test, the interaction between experimenter and animal, sources of variability, the sensory modality required by the animal to solve the task as well as costs and required work effort. Of particular importance is a test's validity because of its influence on the chance of successful translation of preclinical results to clinical settings. High validity may, however, have to be balanced against practical constraints and there are no behavioral tests with optimal characteristics. The design and development of new behavioral tests is therefore an ongoing effort and there are now well over one hundred tests described in the contemporary literature. Some of them are well established following extensive use, while others are novel and still unproven. The task of choosing a behavioral test for a particular project may therefore be daunting and the aim of the present review is to provide a structured way to evaluate rodent behavioral tests aimed at drug discovery research.</p>},
  articleno    = {252},
  author       = {Hånell, Anders and Marklund, Niklas},
  issn         = {1662-5153},
  keyword      = {Journal Article,Review},
  language     = {eng},
  pages        = {1--13},
  publisher    = {Frontiers},
  series       = {Frontiers in Behavioral Neuroscience},
  title        = {Structured evaluation of rodent behavioral tests used in drug discovery research},
  url          = {http://dx.doi.org/10.3389/fnbeh.2014.00252},
  volume       = {8},
  year         = {2014},
}