Low Morbidity and Mortality in Children with Severe Traumatic Brain Injury Treated According to the Lund Concept : A Population-Based Study
Réen, Linus LU ; Cederberg, David LU ; Radman, Anna ; Marklund, Niklas LU
; Visse, Edward
LU
and Siesjö, Peter
LU
(2023)
In Journal of Neurotrauma
40(7-8).
p.720-729
- Abstract
Previous reports of mortality and morbidity in pediatric severe traumatic brain injury (TBI) vary considerably, with few population-based studies. Mortality rates from 3-33 % and varying morbidity have been reported, most commonly using the Extended Glasgow Outcome Scale (eGOS). The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing cerebral perfusion pressure (CPP). The aim of the present study was to retrospectively assess mortality and morbidity in a population of pediatric TBI treated according to the Lund concept. All cases of severe pediatric TBI (age <18 years) in the southern region of Sweden during 19 years were identified. Patients were treated according to the... (More)
Previous reports of mortality and morbidity in pediatric severe traumatic brain injury (TBI) vary considerably, with few population-based studies. Mortality rates from 3-33 % and varying morbidity have been reported, most commonly using the Extended Glasgow Outcome Scale (eGOS). The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing cerebral perfusion pressure (CPP). The aim of the present study was to retrospectively assess mortality and morbidity in a population of pediatric TBI treated according to the Lund concept. All cases of severe pediatric TBI (age <18 years) in the southern region of Sweden during 19 years were identified. Patients were treated according to the Lund concept. Mortality, eGOS, ICP, CPP, time in the neurosurgical intensive care unit (NICU), drugs delivered and surgical procedures were recorded. Data were analyzed both by dichotomized outcomes and by ordinal statistics. A total of 135 cases of severe TBI <18 years of age were recorded (incidence 2.0/100000) and 86 patients were admitted to the tertiary NICU. Mortality including all cases was 43% (mortality rate 0.7/100,000) and in NICU 10%. Outcome was good in 60%, moderate in 25%, unfavorable in 15%, with none in a vegetative status. In both dichotomized and ordinal analyses, CPP <40 mm Hg and ICP >15 were associated with poor outcome, supporting current guidelines. However, high CPP also was associated with increased mortality and morbidity, supporting that elevated CPP might increase cerebral edema. In this study, the Lund concept resulted in low mortality and a favorable outcome in a majority of severe pediatric TBI patients; however, randomized controlled trials are warranted to verify this.
(Less)
- author
- Réen, Linus
LU
; Cederberg, David
LU
; Radman, Anna
; Marklund, Niklas
LU
; Visse, Edward
LU
and Siesjö, Peter
LU
- organization
- publishing date
- 2023-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Glasgow Outcome Scale-extended (eGOS), Lund concept, neurointensive care, pediatric, trauma, traumatic brain injury
- in
- Journal of Neurotrauma
- volume
- 40
- issue
- 7-8
- pages
- 10 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:36472219
- scopus:85152162164
- ISSN
- 0897-7151
- DOI
- 10.1089/neu.2022.0116
- language
- English
- LU publication?
- yes
- id
- de92fff4-d8bd-4a2c-abe2-93cf98fe0503
- date added to LUP
- 2023-07-13 14:15:47
- date last changed
- 2024-04-19 23:22:51
@article{de92fff4-d8bd-4a2c-abe2-93cf98fe0503,
abstract = {{<p>Previous reports of mortality and morbidity in pediatric severe traumatic brain injury (TBI) vary considerably, with few population-based studies. Mortality rates from 3-33 % and varying morbidity have been reported, most commonly using the Extended Glasgow Outcome Scale (eGOS). The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing cerebral perfusion pressure (CPP). The aim of the present study was to retrospectively assess mortality and morbidity in a population of pediatric TBI treated according to the Lund concept. All cases of severe pediatric TBI (age <18 years) in the southern region of Sweden during 19 years were identified. Patients were treated according to the Lund concept. Mortality, eGOS, ICP, CPP, time in the neurosurgical intensive care unit (NICU), drugs delivered and surgical procedures were recorded. Data were analyzed both by dichotomized outcomes and by ordinal statistics. A total of 135 cases of severe TBI <18 years of age were recorded (incidence 2.0/100000) and 86 patients were admitted to the tertiary NICU. Mortality including all cases was 43% (mortality rate 0.7/100,000) and in NICU 10%. Outcome was good in 60%, moderate in 25%, unfavorable in 15%, with none in a vegetative status. In both dichotomized and ordinal analyses, CPP <40 mm Hg and ICP >15 were associated with poor outcome, supporting current guidelines. However, high CPP also was associated with increased mortality and morbidity, supporting that elevated CPP might increase cerebral edema. In this study, the Lund concept resulted in low mortality and a favorable outcome in a majority of severe pediatric TBI patients; however, randomized controlled trials are warranted to verify this.</p>}},
author = {{Réen, Linus and Cederberg, David and Radman, Anna and Marklund, Niklas and Visse, Edward and Siesjö, Peter}},
issn = {{0897-7151}},
keywords = {{Glasgow Outcome Scale-extended (eGOS); Lund concept; neurointensive care; pediatric; trauma; traumatic brain injury}},
language = {{eng}},
number = {{7-8}},
pages = {{720--729}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Journal of Neurotrauma}},
title = {{Low Morbidity and Mortality in Children with Severe Traumatic Brain Injury Treated According to the Lund Concept : A Population-Based Study}},
url = {{http://dx.doi.org/10.1089/neu.2022.0116}},
doi = {{10.1089/neu.2022.0116}},
volume = {{40}},
year = {{2023}},
}