Excited-state dynamics of 4-hydroxyisoindoline-1,3-dione and its derivative as fluorescent probes
(2024) In Physical chemistry chemical physics : PCCP 26(17). p.13506-13514- Abstract
Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relevant excited state dynamics. The photoexcited BHID-Bpin relaxes to its ground state via an efficient nonradiative process (∼300 ps) due to the presence of a minimum energy conical intersection between its first excited state and ground state. However, upon reacting with peroxynitrite, the Bpin moiety is cleaved from BHID-Bpin and BHID is... (More)
Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relevant excited state dynamics. The photoexcited BHID-Bpin relaxes to its ground state via an efficient nonradiative process (∼300 ps) due to the presence of a minimum energy conical intersection between its first excited state and ground state. However, upon reacting with peroxynitrite, the Bpin moiety is cleaved from BHID-Bpin and BHID is formed. The formed BHID exhibits strong dual band fluorescence which is caused by an ultrafast excited-state intramolecular proton transfer process (∼1 ps).
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- author
- Zhao, Li ; Jiang, Simin ; He, Yanmei LU ; Wu, Luling ; James, Tony D and Chen, Junsheng
- organization
- publishing date
- 2024-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physical chemistry chemical physics : PCCP
- volume
- 26
- issue
- 17
- pages
- 9 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:85191382797
- pmid:38651980
- ISSN
- 1463-9084
- DOI
- 10.1039/d3cp05777a
- language
- English
- LU publication?
- yes
- id
- deb8eba0-c1b5-4464-b79e-9dd66ea6382b
- date added to LUP
- 2024-05-03 11:55:25
- date last changed
- 2024-05-18 06:27:23
@article{deb8eba0-c1b5-4464-b79e-9dd66ea6382b,
abstract = {{<p>Fluorescent probes have become promising tools for monitoring the concentration of peroxynitrite, which is linked to many diseases. However, despite focusing on developing numerous peroxynitrite based fluorescent probes, limited emphasis is placed on their sensing mechanism. Here, we investigated the sensing mechanism of a peroxynitrite fluorescent probe, named BHID-Bpin, with a focus on the relevant excited state dynamics. The photoexcited BHID-Bpin relaxes to its ground state via an efficient nonradiative process (∼300 ps) due to the presence of a minimum energy conical intersection between its first excited state and ground state. However, upon reacting with peroxynitrite, the Bpin moiety is cleaved from BHID-Bpin and BHID is formed. The formed BHID exhibits strong dual band fluorescence which is caused by an ultrafast excited-state intramolecular proton transfer process (∼1 ps). </p>}},
author = {{Zhao, Li and Jiang, Simin and He, Yanmei and Wu, Luling and James, Tony D and Chen, Junsheng}},
issn = {{1463-9084}},
language = {{eng}},
month = {{05}},
number = {{17}},
pages = {{13506--13514}},
publisher = {{Royal Society of Chemistry}},
series = {{Physical chemistry chemical physics : PCCP}},
title = {{Excited-state dynamics of 4-hydroxyisoindoline-1,3-dione and its derivative as fluorescent probes}},
url = {{http://dx.doi.org/10.1039/d3cp05777a}},
doi = {{10.1039/d3cp05777a}},
volume = {{26}},
year = {{2024}},
}