Detection of cell-cyclic elements in mis-sampled gene expression data using a robust Capon estimator
Bowles, Thomas ; Jakobsson, Andreas LU
and Chambers, Jonathon A.
(2004)
IEEE International Conference on Acoustics, Speech and Signal Processing, 2004
5.
p.417-420
- Abstract
- We present a method for the estimation of possible cell-cyclic elements in mis-sampled microarray data. Accurate assessment of the frequency content of microarray data gives insight into genes which could be cell-cycle regulated. Cell-cycle regulation is one component of the complex network of genetic regulatory processes and is especially relevant to the study of cancer. As cDNA microarray experiments involve human sampling of cell populations, slight variations in the sampling times invariably occur. We propose estimating the frequency content of microarray data using the recent robust Capon estimator, and formulate a suitable uncertainty region over which to minimize. The estimator is shown to yield robust estimates with real microarray... (More)
- We present a method for the estimation of possible cell-cyclic elements in mis-sampled microarray data. Accurate assessment of the frequency content of microarray data gives insight into genes which could be cell-cycle regulated. Cell-cycle regulation is one component of the complex network of genetic regulatory processes and is especially relevant to the study of cancer. As cDNA microarray experiments involve human sampling of cell populations, slight variations in the sampling times invariably occur. We propose estimating the frequency content of microarray data using the recent robust Capon estimator, and formulate a suitable uncertainty region over which to minimize. The estimator is shown to yield robust estimates with real microarray data and to identify cell-cyclic genes that elude both the traditional periodogram and the Capon spectral estimator (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1217990
- author
- Bowles, Thomas
; Jakobsson, Andreas
LU
and Chambers, Jonathon A.
- publishing date
- 2004
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- cancer, cellular biophysics, DNA, estimation theory, genetics, parameter estimation, cell-cyclic elements detection, mis-sampled gene expression data, robust Capon estimator, frequency content, cell-cycle regulation, genetic regulatory processes, cDNA microarray experiments, minimization, eriodogram, Capon spectral estimator
- host publication
- 2004 IEEE International Conference on Acoustics, Speech, and Signal Processing
- volume
- 5
- pages
- 417 - 420
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- IEEE International Conference on Acoustics, Speech and Signal Processing, 2004
- conference location
- Montreal, Canada
- conference dates
- 2004-05-17 - 2004-05-21
- external identifiers
-
- scopus:4544375199
- ISBN
- 0 7803 8484 9
- language
- English
- LU publication?
- no
- id
- df5389ef-eea6-4b40-87cd-26b2b55ab27d (old id 1217990)
- date added to LUP
- 2016-04-04 10:00:23
- date last changed
- 2022-01-29 19:37:28
@inproceedings{df5389ef-eea6-4b40-87cd-26b2b55ab27d,
abstract = {{We present a method for the estimation of possible cell-cyclic elements in mis-sampled microarray data. Accurate assessment of the frequency content of microarray data gives insight into genes which could be cell-cycle regulated. Cell-cycle regulation is one component of the complex network of genetic regulatory processes and is especially relevant to the study of cancer. As cDNA microarray experiments involve human sampling of cell populations, slight variations in the sampling times invariably occur. We propose estimating the frequency content of microarray data using the recent robust Capon estimator, and formulate a suitable uncertainty region over which to minimize. The estimator is shown to yield robust estimates with real microarray data and to identify cell-cyclic genes that elude both the traditional periodogram and the Capon spectral estimator}},
author = {{Bowles, Thomas and Jakobsson, Andreas and Chambers, Jonathon A.}},
booktitle = {{2004 IEEE International Conference on Acoustics, Speech, and Signal Processing}},
isbn = {{0 7803 8484 9}},
keywords = {{cancer; cellular biophysics; DNA; estimation theory; genetics; parameter estimation; cell-cyclic elements detection; mis-sampled gene expression data; robust Capon estimator; frequency content; cell-cycle regulation; genetic regulatory processes; cDNA microarray experiments; minimization; eriodogram; Capon spectral estimator}},
language = {{eng}},
pages = {{417--420}},
publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}},
title = {{Detection of cell-cyclic elements in mis-sampled gene expression data using a robust Capon estimator}},
volume = {{5}},
year = {{2004}},
}