IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models.
Fritzell, Sara LU ; Eberstål, Sofia LU ; Sandén, Emma LU ; Visse, Edward LU ; Darabi, Anna LU and Siesjö, Peter LU
(2013)
In Journal of Neuroimmunology
258(1-2).
p.91-95
- Abstract
- Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3627704
- author
- Fritzell, Sara
LU
; Eberstål, Sofia
LU
; Sandén, Emma
LU
; Visse, Edward
LU
; Darabi, Anna
LU
and Siesjö, Peter
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuroimmunology
- volume
- 258
- issue
- 1-2
- pages
- 91 - 95
- publisher
- Elsevier
- external identifiers
-
- wos:000318837700013
- pmid:23528658
- scopus:84876723756
- pmid:23528658
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2013.02.017
- language
- English
- LU publication?
- yes
- id
- df5b757b-9ae7-4949-aef1-19683f3cd5da (old id 3627704)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23528658?dopt=Abstract
- date added to LUP
- 2016-04-01 10:38:39
- date last changed
- 2022-01-26 01:07:46
@article{df5b757b-9ae7-4949-aef1-19683f3cd5da,
abstract = {{Peripheral immunization, using a combination of interferon-gamma (IFNγ)- and interleukin-7 (IL-7)-producing tumor cells, eradicated 75% of pre-established intracerebral N32 rat glioma tumors, and prolonged survival in the more aggressive RG2 model. Rats immunized with IFNγ- and IL7-transduced N32 cells displayed increases in IFNγ plasma levels and proliferating circulating T cells when compared with rats immunized with N32-wild type cells. Following irradiation, the expression of MHC I and II was high on N32-IFNγ cells, but low on RG2-IFNγ cells. In conclusion, IFNγ and IL-7 immunizations prolong survival in two rat glioma models.}},
author = {{Fritzell, Sara and Eberstål, Sofia and Sandén, Emma and Visse, Edward and Darabi, Anna and Siesjö, Peter}},
issn = {{1872-8421}},
language = {{eng}},
number = {{1-2}},
pages = {{91--95}},
publisher = {{Elsevier}},
series = {{Journal of Neuroimmunology}},
title = {{IFNγ in combination with IL-7 enhances immunotherapy in two rat glioma models.}},
url = {{http://dx.doi.org/10.1016/j.jneuroim.2013.02.017}},
doi = {{10.1016/j.jneuroim.2013.02.017}},
volume = {{258}},
year = {{2013}},
}