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Time as a Therapeutic Ally : The Promise of Long-Term Solid Organ and Tissue Perfusion

Huwyler, Florian ; Pfister, Matthias ; Phuyal, Diwakar ; Dean, Yomna E. ; Mittendorfer, Margareta LU ; Saemann, Lars ; Rasel, Hannah ; Stoerzer, Simon ; Binz, Jonas and Tabatabaei, Bahareh , et al. (2026) In Transplant International 39(9). p.1-17
Abstract

Rapid advances in tissue preservation and the growing adoption of machine perfusion have fundamentally reshaped solid-organ and tissue transplantation in recent years. Multiple short-term perfusion devices have received regulatory approval and are increasingly used in clinical practice to preserve grafts for several hours, improving allograft assessment. The boundaries of dynamic tissue preservation have been pushed even further in research settings, where grafts have been reliably perfused for multiple days. The extended time of long-term machine perfusion opens a new therapeutic window for interventions, allowing for reconditioning and even tissue repair of injured and diseased grafts. The increasing global organ shortage makes these... (More)

Rapid advances in tissue preservation and the growing adoption of machine perfusion have fundamentally reshaped solid-organ and tissue transplantation in recent years. Multiple short-term perfusion devices have received regulatory approval and are increasingly used in clinical practice to preserve grafts for several hours, improving allograft assessment. The boundaries of dynamic tissue preservation have been pushed even further in research settings, where grafts have been reliably perfused for multiple days. The extended time of long-term machine perfusion opens a new therapeutic window for interventions, allowing for reconditioning and even tissue repair of injured and diseased grafts. The increasing global organ shortage makes these approaches particularly attractive to recover additional allografts for safe transplantation. In this review, we highlight current clinical practice for ex situ perfused allografts, multi-day perfusions in research settings, and potential therapeutic benefits of long-term perfusion with a focus on hearts, livers, lungs and vascularized composite allografts.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
heart, kidney, liver, lung, transplant, vascularized composite allografts
in
Transplant International
volume
39
issue
9
article number
16100
pages
17 pages
publisher
Springer
external identifiers
  • scopus:105038173872
  • pmid:42077424
ISSN
0934-0874
DOI
10.3389/ti.2026.16100
language
English
LU publication?
yes
id
df796e87-f416-4d91-953a-3a2323a044b4
date added to LUP
2026-07-10 13:33:15
date last changed
2026-07-11 03:00:03
@article{df796e87-f416-4d91-953a-3a2323a044b4,
  abstract     = {{<p>Rapid advances in tissue preservation and the growing adoption of machine perfusion have fundamentally reshaped solid-organ and tissue transplantation in recent years. Multiple short-term perfusion devices have received regulatory approval and are increasingly used in clinical practice to preserve grafts for several hours, improving allograft assessment. The boundaries of dynamic tissue preservation have been pushed even further in research settings, where grafts have been reliably perfused for multiple days. The extended time of long-term machine perfusion opens a new therapeutic window for interventions, allowing for reconditioning and even tissue repair of injured and diseased grafts. The increasing global organ shortage makes these approaches particularly attractive to recover additional allografts for safe transplantation. In this review, we highlight current clinical practice for ex situ perfused allografts, multi-day perfusions in research settings, and potential therapeutic benefits of long-term perfusion with a focus on hearts, livers, lungs and vascularized composite allografts.</p>}},
  author       = {{Huwyler, Florian and Pfister, Matthias and Phuyal, Diwakar and Dean, Yomna E. and Mittendorfer, Margareta and Saemann, Lars and Rasel, Hannah and Stoerzer, Simon and Binz, Jonas and Tabatabaei, Bahareh and Szabo, Gabor and Lindstedt, Sandra and Bassiri Gharb, Bahar and Tibbitt, Mark W. and Clavien, Pierre Alain}},
  issn         = {{0934-0874}},
  keywords     = {{heart; kidney; liver; lung; transplant; vascularized composite allografts}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{1--17}},
  publisher    = {{Springer}},
  series       = {{Transplant International}},
  title        = {{Time as a Therapeutic Ally : The Promise of Long-Term Solid Organ and Tissue Perfusion}},
  url          = {{http://dx.doi.org/10.3389/ti.2026.16100}},
  doi          = {{10.3389/ti.2026.16100}},
  volume       = {{39}},
  year         = {{2026}},
}