Advanced

Predictive properties of the A-TAC inventory when screening for childhood-onset neurodevelopmental problems in a population-based sample

Larson, Tomas LU ; Lundstom, Sebastian; Nilsson, Thomas; Selinus, Eva Noren; Råstam, Maria LU ; Lichtenstein, Paul; Gumpert, Clara Hellner; Anckarsäter, Henrik LU and Kerekes, Nora (2013) In BMC Psychiatry 13.
Abstract
Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also clinically useful to prioritize children for comprehensive assessments, to screen risk groups, and to follow controls. Autism-Tics, ADHD, and other Co-morbidities inventory (A-TAC) was developed to meet these requirements; here the A-TAC's prospective and psychometric properties are examined, when used in a population-based, epidemiological setting.... (More)
Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also clinically useful to prioritize children for comprehensive assessments, to screen risk groups, and to follow controls. Autism-Tics, ADHD, and other Co-morbidities inventory (A-TAC) was developed to meet these requirements; here the A-TAC's prospective and psychometric properties are examined, when used in a population-based, epidemiological setting. Methods: Since 2004, parents of all Swedish twins have been asked to take part in an ongoing, nation-wide twin study (The Child and Adolescent Twin Study in Sweden). The study includes the A-TAC, carried out as a telephone interview with parents of twins aged 9 or 12. In the present study, screen-positive twins from three birth year cohorts (1993-1995) were invited to a comprehensive clinical follow-up (blinded for previous screening results) together with their co-twins and randomly selected, healthy controls at age 15 (Total N = 452). Results: Sensitivity and specificity of A-TAC scores for predicting later clinical diagnoses were good to excellent overall, with values of the area under the receiver operating characteristics curves ranging from 0.77 (AD/HD) to 0.91 (ASDs). Among children who were screen-positive for an ASD, 48% received a clinical diagnosis of ASDs. For AD/HD, the corresponding figure was also 48%, for LDs 16%, and for TDs 60%. Between 4% and 35% of screen-positive children did not receive any diagnosis at the clinical follow-up three years later. Among screen-negative controls, prevalence of ASDs, AD/HD, LDs, and TDs was 0%, 7%, 4%, and 2%, respectively. Conclusions: The A-TAC appeared to be a valid instrument to assess NDPs in this population-based, longitudinal study. It has good-to-excellent psychometric properties, with an excellent ability to distinguish NDPs (mainly ASDs) from non-NDPs at least three years after the screening evaluations, although specific diagnoses did not correspond closely to actual clinical diagnoses. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Mental disorders diagnosed in childhood, Screening, and other Co-morbidities inventory, AD/HD, Tics, Autism, A-TAC, Co-morbidity, Cohort, studies, Predictive value of tests, Sensitivity and specificity
in
BMC Psychiatry
volume
13
publisher
BioMed Central
external identifiers
  • wos:000325144900001
  • scopus:84884524352
ISSN
1471-244X
DOI
10.1186/1471-244X-13-233
language
English
LU publication?
yes
id
df993327-c6a6-401a-8ba1-75f615f7982e (old id 4172181)
date added to LUP
2013-12-06 12:31:36
date last changed
2019-05-14 02:14:13
@article{df993327-c6a6-401a-8ba1-75f615f7982e,
  abstract     = {Background: Identifying children with childhood-onset neurodevelopmental problems (NDPs, defined here as autism spectrum disorders [ASDs], attention-deficit/hyperactivity disorder [AD/HD], tic disorders [TDs], learning disorders [LDs] and development coordination disorder), using easily administered screening instruments, is a prerequisite for epidemiological research. Such instruments are also clinically useful to prioritize children for comprehensive assessments, to screen risk groups, and to follow controls. Autism-Tics, ADHD, and other Co-morbidities inventory (A-TAC) was developed to meet these requirements; here the A-TAC's prospective and psychometric properties are examined, when used in a population-based, epidemiological setting. Methods: Since 2004, parents of all Swedish twins have been asked to take part in an ongoing, nation-wide twin study (The Child and Adolescent Twin Study in Sweden). The study includes the A-TAC, carried out as a telephone interview with parents of twins aged 9 or 12. In the present study, screen-positive twins from three birth year cohorts (1993-1995) were invited to a comprehensive clinical follow-up (blinded for previous screening results) together with their co-twins and randomly selected, healthy controls at age 15 (Total N = 452). Results: Sensitivity and specificity of A-TAC scores for predicting later clinical diagnoses were good to excellent overall, with values of the area under the receiver operating characteristics curves ranging from 0.77 (AD/HD) to 0.91 (ASDs). Among children who were screen-positive for an ASD, 48% received a clinical diagnosis of ASDs. For AD/HD, the corresponding figure was also 48%, for LDs 16%, and for TDs 60%. Between 4% and 35% of screen-positive children did not receive any diagnosis at the clinical follow-up three years later. Among screen-negative controls, prevalence of ASDs, AD/HD, LDs, and TDs was 0%, 7%, 4%, and 2%, respectively. Conclusions: The A-TAC appeared to be a valid instrument to assess NDPs in this population-based, longitudinal study. It has good-to-excellent psychometric properties, with an excellent ability to distinguish NDPs (mainly ASDs) from non-NDPs at least three years after the screening evaluations, although specific diagnoses did not correspond closely to actual clinical diagnoses.},
  articleno    = {233},
  author       = {Larson, Tomas and Lundstom, Sebastian and Nilsson, Thomas and Selinus, Eva Noren and Råstam, Maria and Lichtenstein, Paul and Gumpert, Clara Hellner and Anckarsäter, Henrik and Kerekes, Nora},
  issn         = {1471-244X},
  keyword      = {Mental disorders diagnosed in childhood,Screening,and other Co-morbidities inventory,AD/HD,Tics,Autism,A-TAC,Co-morbidity,Cohort,studies,Predictive value of tests,Sensitivity and specificity},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Psychiatry},
  title        = {Predictive properties of the A-TAC inventory when screening for childhood-onset neurodevelopmental problems in a population-based sample},
  url          = {http://dx.doi.org/10.1186/1471-244X-13-233},
  volume       = {13},
  year         = {2013},
}