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Clinical Management and Transplant Considerations in Pediatric Pulmonary Hypertension Due to Left Heart Disease : A Scientific Statement From the American Heart Association

Hopper, Rachel K ; Hansmann, Georg ; Hollander, Seth A ; Dipchand, Anne I ; van der Have, Oscar LU orcid ; Iler, Colleen ; Herrington, Cynthia ; Rosenzweig, Erika B ; Alejos, Juan C and Tran-Lundmark, Karin LU (2024) In Circulation. Heart failure
Abstract

Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased afterload and is an important consideration for heart transplant eligibility. However, the epidemiology, pathophysiology, optimal diagnostic and treatment approaches, and thresholds for pulmonary vascular resistance in pulmonary hypertension associated with left heart disease remain unclear because of lack of evidence, particularly in... (More)

Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased afterload and is an important consideration for heart transplant eligibility. However, the epidemiology, pathophysiology, optimal diagnostic and treatment approaches, and thresholds for pulmonary vascular resistance in pulmonary hypertension associated with left heart disease remain unclear because of lack of evidence, particularly in pediatrics. The result is heterogeneity with respect to hemodynamic assessment, use of pulmonary vasodilator therapies, and heart transplant listing. This scientific statement aims to synthesize the available data and highlight areas of general consensus as well as important knowledge gaps.

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author collaboration
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publishing date
type
Contribution to journal
publication status
epub
subject
in
Circulation. Heart failure
article number
e000086
publisher
American Heart Association
external identifiers
  • scopus:85212140298
  • pmid:39648916
ISSN
1941-3297
DOI
10.1161/HHF.0000000000000086
language
English
LU publication?
yes
id
dfa681cd-3aff-4895-9642-d444181ee1b3
date added to LUP
2024-12-11 14:24:18
date last changed
2025-07-10 11:52:49
@article{dfa681cd-3aff-4895-9642-d444181ee1b3,
  abstract     = {{<p>Children with left heart disease are at risk for developing pulmonary hypertension, initially secondary to pulmonary venous hypertension that can progress to include elevated pulmonary vascular resistance, known as combined pre- and postcapillary pulmonary hypertension. Elevated pulmonary vascular resistance may pose a risk to the right ventricle of a newly transplanted heart because of increased afterload and is an important consideration for heart transplant eligibility. However, the epidemiology, pathophysiology, optimal diagnostic and treatment approaches, and thresholds for pulmonary vascular resistance in pulmonary hypertension associated with left heart disease remain unclear because of lack of evidence, particularly in pediatrics. The result is heterogeneity with respect to hemodynamic assessment, use of pulmonary vasodilator therapies, and heart transplant listing. This scientific statement aims to synthesize the available data and highlight areas of general consensus as well as important knowledge gaps.</p>}},
  author       = {{Hopper, Rachel K and Hansmann, Georg and Hollander, Seth A and Dipchand, Anne I and van der Have, Oscar and Iler, Colleen and Herrington, Cynthia and Rosenzweig, Erika B and Alejos, Juan C and Tran-Lundmark, Karin}},
  issn         = {{1941-3297}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{American Heart Association}},
  series       = {{Circulation. Heart failure}},
  title        = {{Clinical Management and Transplant Considerations in Pediatric Pulmonary Hypertension Due to Left Heart Disease : A Scientific Statement From the American Heart Association}},
  url          = {{http://dx.doi.org/10.1161/HHF.0000000000000086}},
  doi          = {{10.1161/HHF.0000000000000086}},
  year         = {{2024}},
}