Uromodulin gene variant is associated with type 2 diabetic nephropathy.
Ahluwalia, Tarunveer S ; Lindholm, Eero LU ; Groop, Leif LU and Melander, Olle LU
(2011)
In Journal of Hypertension
29.
p.1731-1734
- Abstract
- AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney disease (CKD). In the present study we examined the association of the common variant of the uromodulin (UMOD) gene with type 2 diabetic nephropathy and kidney function. METHODS: UMOD variant rs13333226 was genotyped in a case-control material including 4888 unrelated type 2 diabetic individuals (n = 880 with and n = 4008 without nephropathy) from... (More)
- AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney disease (CKD). In the present study we examined the association of the common variant of the uromodulin (UMOD) gene with type 2 diabetic nephropathy and kidney function. METHODS: UMOD variant rs13333226 was genotyped in a case-control material including 4888 unrelated type 2 diabetic individuals (n = 880 with and n = 4008 without nephropathy) from Sweden (Scania Diabetes Registry) using the ABI Real time TaqMan allelic discrimination assay. RESULTS: The G allele of rs13333226 was associated with a decreased risk of nephropathy [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.69-0.91, P = 0.001] after correction for confounding factors like age, sex, body mass index (BMI), blood pressure, kidney function, smoking and duration of diabetes. The same allele was also associated with a better kidney function [estimated glomerular filtration rate (eGFR), β = 0.117, P < 0.0001] and lower systolic blood pressure (β = -0.048, P = 0.013) in the overall study cohort. CONCLUSION/INTERPRETATION: The present study highlights that the common variant of the UMOD gene is protective against diabetic nephropathy susceptibility and also affects kidney function and blood pressure in patients with type 2 diabetes. However, the association with diabetic nephropathy was independent of blood pressure and kidney function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058839
- author
- Ahluwalia, Tarunveer S
; Lindholm, Eero
LU
; Groop, Leif
LU
and Melander, Olle
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hypertension
- volume
- 29
- pages
- 1731 - 1734
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000293825600009
- pmid:21738052
- scopus:80051952270
- pmid:21738052
- ISSN
- 1473-5598
- DOI
- 10.1097/HJH.0b013e328349de25
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Hypertension and Cardiovascular Disease (013242540), Diabetes and Endocrinology (013241530)
- id
- dfc6cad5-f45d-4d53-b5cb-c378b33b4565 (old id 2058839)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21738052?dopt=Abstract
- date added to LUP
- 2016-04-04 09:37:50
- date last changed
- 2024-03-14 02:48:44
@article{dfc6cad5-f45d-4d53-b5cb-c378b33b4565,
abstract = {{AIMS/HYPOTHESIS: About 35% of individuals with type 2 diabetes develop persistent albuminuria, lose renal function, and are at increased risk for microvascular complications like diabetic nephropathy. Recent genome-wide association studies have identified the uromodulin locus (UMOD), encoding the most common protein in human urine to be associated with hypertension and also with chronic kidney disease (CKD). In the present study we examined the association of the common variant of the uromodulin (UMOD) gene with type 2 diabetic nephropathy and kidney function. METHODS: UMOD variant rs13333226 was genotyped in a case-control material including 4888 unrelated type 2 diabetic individuals (n = 880 with and n = 4008 without nephropathy) from Sweden (Scania Diabetes Registry) using the ABI Real time TaqMan allelic discrimination assay. RESULTS: The G allele of rs13333226 was associated with a decreased risk of nephropathy [odds ratio (OR) 0.80, 95% confidence interval (CI) 0.69-0.91, P = 0.001] after correction for confounding factors like age, sex, body mass index (BMI), blood pressure, kidney function, smoking and duration of diabetes. The same allele was also associated with a better kidney function [estimated glomerular filtration rate (eGFR), β = 0.117, P < 0.0001] and lower systolic blood pressure (β = -0.048, P = 0.013) in the overall study cohort. CONCLUSION/INTERPRETATION: The present study highlights that the common variant of the UMOD gene is protective against diabetic nephropathy susceptibility and also affects kidney function and blood pressure in patients with type 2 diabetes. However, the association with diabetic nephropathy was independent of blood pressure and kidney function.}},
author = {{Ahluwalia, Tarunveer S and Lindholm, Eero and Groop, Leif and Melander, Olle}},
issn = {{1473-5598}},
language = {{eng}},
pages = {{1731--1734}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Uromodulin gene variant is associated with type 2 diabetic nephropathy.}},
url = {{http://dx.doi.org/10.1097/HJH.0b013e328349de25}},
doi = {{10.1097/HJH.0b013e328349de25}},
volume = {{29}},
year = {{2011}},
}