Advanced

High serum total cholesterol is associated with suicide mortality in Japanese women

Svensson, T LU ; Inoue, Manami; Sawada, Norie; Charvat, Hadrien; Mimura, Masaru and Tsugane, Shoichiro (2017) In Acta psychiatrica Scandinavica 136(3). p.259-268
Abstract

OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.

METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.

RESULTS: There were 185 suicides (men: 107;... (More)

OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.

METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.

RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.

CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta psychiatrica Scandinavica
volume
136
issue
3
pages
259 - 268
publisher
Wiley-Blackwell
external identifiers
  • scopus:85019752758
  • wos:000407010600004
ISSN
1600-0447
DOI
10.1111/acps.12758
language
English
LU publication?
yes
id
dfe241c8-368e-4b06-b875-bfeee4d5d0f7
date added to LUP
2017-05-27 23:24:26
date last changed
2017-09-18 11:37:36
@article{dfe241c8-368e-4b06-b875-bfeee4d5d0f7,
  abstract     = {<p>OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.</p><p>METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (&lt;4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.</p><p>RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.</p><p>CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.</p>},
  author       = {Svensson, T and Inoue, Manami and Sawada, Norie and Charvat, Hadrien and Mimura, Masaru and Tsugane, Shoichiro},
  issn         = {1600-0447},
  language     = {eng},
  month        = {05},
  number       = {3},
  pages        = {259--268},
  publisher    = {Wiley-Blackwell},
  series       = {Acta psychiatrica Scandinavica},
  title        = {High serum total cholesterol is associated with suicide mortality in Japanese women},
  url          = {http://dx.doi.org/10.1111/acps.12758},
  volume       = {136},
  year         = {2017},
}