High serum total cholesterol is associated with suicide mortality in Japanese women
(2017) In Acta Psychiatrica Scandinavica 136(3). p.259-268- Abstract
OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.
METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.
RESULTS: There were 185 suicides (men: 107;... (More)
OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.
METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.
RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.
CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.
(Less)
- author
- Svensson, T LU ; Inoue, Manami ; Sawada, Norie ; Charvat, Hadrien ; Mimura, Masaru and Tsugane, Shoichiro
- organization
- publishing date
- 2017-05-26
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Psychiatrica Scandinavica
- volume
- 136
- issue
- 3
- pages
- 259 - 268
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85019752758
- wos:000407010600004
- pmid:28547796
- ISSN
- 1600-0447
- DOI
- 10.1111/acps.12758
- language
- English
- LU publication?
- yes
- id
- dfe241c8-368e-4b06-b875-bfeee4d5d0f7
- date added to LUP
- 2017-05-27 23:24:26
- date last changed
- 2025-01-07 14:19:20
@article{dfe241c8-368e-4b06-b875-bfeee4d5d0f7, abstract = {{<p>OBJECTIVE: To investigate the association between serum total cholesterol (TC) and suicide using a large general population cohort with long follow-up times.</p><p>METHOD: Analyses included 16 341 men and 28 905 women aged 40-69 from the Japan Public Health Center-based Prospective Study followed from 1990 to 2012. TC levels were defined per clinical guidelines: low (<4.66 mmol/l [180 mg/dl]), normal (4.66-5.70 mmol/l [180-220 mg/dl]), and high (≥5.70 mmol/l [220 mg/dl]). Cox proportional hazards regression models were used to determine hazard ratios (HR) and confidence intervals (CI) for suicide according to TC level. Mean follow-up time was 19 years for men and 20 years for women.</p><p>RESULTS: There were 185 suicides (men: 107; women: 78) during follow-up. Compared to women with normal TC, women with high TC had a significantly increased risk of suicide (HR = 1.90, 95% CI, 1.13-3.19). Incremental increases (0.26 mmol/l [10 mg/dl]) of low-density lipoprotein (HR = 1.11, 95% CI, 1.02-1.21) and non-high-density lipoprotein cholesterol (HR = 1.09, 95% CI, 1.01-1.18) were also associated with increased risk of suicide in women. There was no association between TC levels, or lipid fractions, and suicide in men.</p><p>CONCLUSION: High TC levels may be associated with an increased risk of suicide in women.</p>}}, author = {{Svensson, T and Inoue, Manami and Sawada, Norie and Charvat, Hadrien and Mimura, Masaru and Tsugane, Shoichiro}}, issn = {{1600-0447}}, language = {{eng}}, month = {{05}}, number = {{3}}, pages = {{259--268}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Psychiatrica Scandinavica}}, title = {{High serum total cholesterol is associated with suicide mortality in Japanese women}}, url = {{http://dx.doi.org/10.1111/acps.12758}}, doi = {{10.1111/acps.12758}}, volume = {{136}}, year = {{2017}}, }