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Comparison of low dose nicotinamide versus benzamide, administered per os, as radiosensitizers in a C3H mammary carcinoma

Kjellén, Elisabeth LU ; Pero, Ronald LU and Nilsson, Per LU orcid (1988) In Radiotherapy and Oncology 12(4). p.327-331
Abstract
We have evaluated if any differences in tumor radiosensitization exist between the two adenosine diphosphate ribosyl transferase (ADPRT) inhibitors nicotinamide and benzamide at fractionated low doses. A significant radiosensitizing effect with nicotinamide at a 10 mg/kg per day dose was found in the tumor model used. We found, however, no radiosensitizing effect with benzamide given according to this schedule.
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Radiosensitization, in vivo, C3H-tumor, Benzamide, Nicotinamide
in
Radiotherapy and Oncology
volume
12
issue
4
pages
327 - 331
publisher
Elsevier
external identifiers
  • pmid:2973086
  • scopus:0023770760
ISSN
1879-0887
DOI
10.1016/0167-8140(88)90022-9
language
English
LU publication?
yes
id
e00a9852-7a46-4889-88d0-0f04c1b0d076 (old id 1104104)
date added to LUP
2016-04-01 12:11:54
date last changed
2021-01-03 04:25:29
@article{e00a9852-7a46-4889-88d0-0f04c1b0d076,
  abstract     = {{We have evaluated if any differences in tumor radiosensitization exist between the two adenosine diphosphate ribosyl transferase (ADPRT) inhibitors nicotinamide and benzamide at fractionated low doses. A significant radiosensitizing effect with nicotinamide at a 10 mg/kg per day dose was found in the tumor model used. We found, however, no radiosensitizing effect with benzamide given according to this schedule.}},
  author       = {{Kjellén, Elisabeth and Pero, Ronald and Nilsson, Per}},
  issn         = {{1879-0887}},
  keywords     = {{Radiosensitization; in vivo; C3H-tumor; Benzamide; Nicotinamide}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{327--331}},
  publisher    = {{Elsevier}},
  series       = {{Radiotherapy and Oncology}},
  title        = {{Comparison of low dose nicotinamide versus benzamide, administered per os, as radiosensitizers in a C3H mammary carcinoma}},
  url          = {{http://dx.doi.org/10.1016/0167-8140(88)90022-9}},
  doi          = {{10.1016/0167-8140(88)90022-9}},
  volume       = {{12}},
  year         = {{1988}},
}