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Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges

Khoptyar, Dmitry LU ; Subash, Arman LU ; Johansson, Soren; Saleem, Muhammad; Sparen, Anders; Johansson, Jonas and Andersson-Engels, Stefan LU (2013) In Optics Express 21(18). p.20941-20953
Abstract
We present extended spectroscopic analysis of pharmaceutical tablets in the close near infrared spectral range performed using broadband photon time-of-flight (PTOF) absorption and scattering spectra measurements. We show that the absorption spectra can be used to perform evaluation of the chemical composition of pharmaceutical tablets without need for chemo-metric calibration. The spectroscopic analysis was performed using an advanced PTOF spectrometer operating in the 650 to 1400 nm spectral range. By employing temporal stabilization of the system we achieve the high precision of 0.5% required to evaluate the concentration of tablet ingredients. In order to further illustrate the performance of the system, we present the first ever... (More)
We present extended spectroscopic analysis of pharmaceutical tablets in the close near infrared spectral range performed using broadband photon time-of-flight (PTOF) absorption and scattering spectra measurements. We show that the absorption spectra can be used to perform evaluation of the chemical composition of pharmaceutical tablets without need for chemo-metric calibration. The spectroscopic analysis was performed using an advanced PTOF spectrometer operating in the 650 to 1400 nm spectral range. By employing temporal stabilization of the system we achieve the high precision of 0.5% required to evaluate the concentration of tablet ingredients. In order to further illustrate the performance of the system, we present the first ever reported broadband evaluation of absorption and scattering spectra from pure and doped Spectralon (R). (C) 2013 Optical Society of America (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
21
issue
18
pages
20941 - 20953
publisher
OSA
external identifiers
  • wos:000324867100060
  • scopus:84884558854
ISSN
1094-4087
DOI
10.1364/OE.21.020941
language
English
LU publication?
yes
id
e01df7e0-7804-4562-be7f-d1dce471be14 (old id 4172560)
date added to LUP
2013-11-20 16:08:41
date last changed
2019-06-11 02:04:01
@article{e01df7e0-7804-4562-be7f-d1dce471be14,
  abstract     = {We present extended spectroscopic analysis of pharmaceutical tablets in the close near infrared spectral range performed using broadband photon time-of-flight (PTOF) absorption and scattering spectra measurements. We show that the absorption spectra can be used to perform evaluation of the chemical composition of pharmaceutical tablets without need for chemo-metric calibration. The spectroscopic analysis was performed using an advanced PTOF spectrometer operating in the 650 to 1400 nm spectral range. By employing temporal stabilization of the system we achieve the high precision of 0.5% required to evaluate the concentration of tablet ingredients. In order to further illustrate the performance of the system, we present the first ever reported broadband evaluation of absorption and scattering spectra from pure and doped Spectralon (R). (C) 2013 Optical Society of America},
  author       = {Khoptyar, Dmitry and Subash, Arman and Johansson, Soren and Saleem, Muhammad and Sparen, Anders and Johansson, Jonas and Andersson-Engels, Stefan},
  issn         = {1094-4087},
  language     = {eng},
  number       = {18},
  pages        = {20941--20953},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges},
  url          = {http://dx.doi.org/10.1364/OE.21.020941},
  volume       = {21},
  year         = {2013},
}