Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges
(2013) In Optics Express 21(18). p.20941-20953- Abstract
- We present extended spectroscopic analysis of pharmaceutical tablets in the close near infrared spectral range performed using broadband photon time-of-flight (PTOF) absorption and scattering spectra measurements. We show that the absorption spectra can be used to perform evaluation of the chemical composition of pharmaceutical tablets without need for chemo-metric calibration. The spectroscopic analysis was performed using an advanced PTOF spectrometer operating in the 650 to 1400 nm spectral range. By employing temporal stabilization of the system we achieve the high precision of 0.5% required to evaluate the concentration of tablet ingredients. In order to further illustrate the performance of the system, we present the first ever... (More)
- We present extended spectroscopic analysis of pharmaceutical tablets in the close near infrared spectral range performed using broadband photon time-of-flight (PTOF) absorption and scattering spectra measurements. We show that the absorption spectra can be used to perform evaluation of the chemical composition of pharmaceutical tablets without need for chemo-metric calibration. The spectroscopic analysis was performed using an advanced PTOF spectrometer operating in the 650 to 1400 nm spectral range. By employing temporal stabilization of the system we achieve the high precision of 0.5% required to evaluate the concentration of tablet ingredients. In order to further illustrate the performance of the system, we present the first ever reported broadband evaluation of absorption and scattering spectra from pure and doped Spectralon (R). (C) 2013 Optical Society of America (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4172560
- author
- Khoptyar, Dmitry LU ; Subash, Arman LU ; Johansson, Soren ; Saleem, Muhammad ; Sparen, Anders ; Johansson, Jonas and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Optics Express
- volume
- 21
- issue
- 18
- pages
- 20941 - 20953
- publisher
- Optical Society of America
- external identifiers
-
- wos:000324867100060
- scopus:84884558854
- ISSN
- 1094-4087
- DOI
- 10.1364/OE.21.020941
- language
- English
- LU publication?
- yes
- id
- e01df7e0-7804-4562-be7f-d1dce471be14 (old id 4172560)
- date added to LUP
- 2016-04-01 13:56:51
- date last changed
- 2022-01-27 22:00:29
@article{e01df7e0-7804-4562-be7f-d1dce471be14, abstract = {{We present extended spectroscopic analysis of pharmaceutical tablets in the close near infrared spectral range performed using broadband photon time-of-flight (PTOF) absorption and scattering spectra measurements. We show that the absorption spectra can be used to perform evaluation of the chemical composition of pharmaceutical tablets without need for chemo-metric calibration. The spectroscopic analysis was performed using an advanced PTOF spectrometer operating in the 650 to 1400 nm spectral range. By employing temporal stabilization of the system we achieve the high precision of 0.5% required to evaluate the concentration of tablet ingredients. In order to further illustrate the performance of the system, we present the first ever reported broadband evaluation of absorption and scattering spectra from pure and doped Spectralon (R). (C) 2013 Optical Society of America}}, author = {{Khoptyar, Dmitry and Subash, Arman and Johansson, Soren and Saleem, Muhammad and Sparen, Anders and Johansson, Jonas and Andersson-Engels, Stefan}}, issn = {{1094-4087}}, language = {{eng}}, number = {{18}}, pages = {{20941--20953}}, publisher = {{Optical Society of America}}, series = {{Optics Express}}, title = {{Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges}}, url = {{http://dx.doi.org/10.1364/OE.21.020941}}, doi = {{10.1364/OE.21.020941}}, volume = {{21}}, year = {{2013}}, }