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The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Weinhold, Niels; Johnson, David C.; Chubb, Daniel; Chen, Bowang; Försti, Asta LU ; Hosking, Fay J.; Broderick, Peter; Ma, Yussanne P.; Dobbins, Sara E. and Hose, Dirk, et al. (2013) In Nature Genetics 45(5). p.522-525
Abstract
A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.
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publication status
published
subject
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Nature Genetics
volume
45
issue
5
pages
522 - 525
publisher
Nature Publishing Group
external identifiers
  • wos:000318158200014
  • scopus:84878596524
ISSN
1546-1718
DOI
10.1038/ng.2583
language
English
LU publication?
yes
id
e035bef8-4504-4724-99cd-fe5d35bec984 (old id 3843820)
date added to LUP
2013-06-20 13:29:21
date last changed
2019-05-12 03:41:56
@article{e035bef8-4504-4724-99cd-fe5d35bec984,
  abstract     = {A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.},
  author       = {Weinhold, Niels and Johnson, David C. and Chubb, Daniel and Chen, Bowang and Försti, Asta and Hosking, Fay J. and Broderick, Peter and Ma, Yussanne P. and Dobbins, Sara E. and Hose, Dirk and Walker, Brian A. and Davies, Faith E. and Kaiser, Martin F. and Li, Ni L. and Gregory, Walter A. and Jackson, Graham H. and Witzens-Harig, Mathias and Neben, Kai and Hoffmann, Per and Noethen, Markus M. and Muehleisen, Thomas W. and Eisele, Lewin and Ross, Fiona M. and Jauch, Anna and Goldschmidt, Hartmut and Houlston, Richard S. and Morgan, Gareth J. and Hemminki, Kari},
  issn         = {1546-1718},
  language     = {eng},
  number       = {5},
  pages        = {522--525},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma},
  url          = {http://dx.doi.org/10.1038/ng.2583},
  volume       = {45},
  year         = {2013},
}