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Host–pathogen interactions of nontypeable Haemophilus influenzae : from commensal to pathogen

Duell, Ben LU ; Su, Yu Ching and Riesbeck, Kristian LU (2016) In FEBS Letters 590(21). p.3840-3853
Abstract

Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is... (More)

Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is multifaceted, that is, using virulence factors involved in complement resistance, biofilm, modified immunoglobulin responses, and, finally, formation and utilization of host proteins as a secondary strategy of increasing the adhesive ability.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adhesion, biofilm formation, extracellular matrix, Haemophilus, intracellular, serum resistance
in
FEBS Letters
volume
590
issue
21
pages
14 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:84992154186
  • wos:000387760500009
ISSN
0014-5793
DOI
10.1002/1873-3468.12351
language
English
LU publication?
yes
id
e0578d30-9fd1-45b4-9b04-ae3d7d64819b
date added to LUP
2016-12-05 09:17:09
date last changed
2017-10-29 04:54:56
@article{e0578d30-9fd1-45b4-9b04-ae3d7d64819b,
  abstract     = {<p>Nontypeable Haemophilus influenzae (NTHi) is a commensal microbe often isolated from the upper and lower respiratory tract. This bacterial species can cause sinusitis, acute otitis media in preschool children, exacerbations in patients suffering from chronic obstructive pulmonary disease, as well as conjunctivitis and bacteremia. Since the introduction of a vaccine against H. influenzae serotype b in the 1990s, the burden of H. influenzae-related infections has been increasingly dominated by NTHi. Understanding the ability of NTHi to cause infection is currently an expanding area of study. NTHi is able to exert differential binding to the host tissue through the use of a broad range of adhesins. NTHi survival in the host is multifaceted, that is, using virulence factors involved in complement resistance, biofilm, modified immunoglobulin responses, and, finally, formation and utilization of host proteins as a secondary strategy of increasing the adhesive ability.</p>},
  author       = {Duell, Ben and Su, Yu Ching and Riesbeck, Kristian},
  issn         = {0014-5793},
  keyword      = {adhesion,biofilm formation,extracellular matrix,Haemophilus,intracellular,serum resistance},
  language     = {eng},
  month        = {11},
  number       = {21},
  pages        = {3840--3853},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Letters},
  title        = {Host–pathogen interactions of nontypeable Haemophilus influenzae : from commensal to pathogen},
  url          = {http://dx.doi.org/10.1002/1873-3468.12351},
  volume       = {590},
  year         = {2016},
}