Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata.
(2009) In Proceedings of the National Academy of Sciences 106(8). p.2688-2693- Abstract
- In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel... (More)
- In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel chromosomes. Apparently, this yeast can generate a new chromosome by duplication of chromosome segments carrying a centromere and subsequently adding novel telomeric ends. We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1302741
- author
- Poláková, Silvia LU ; Blume, Christian ; Zárate, Julián Alvarez ; Mentel, Marek ; Jørck-Ramberg, Dorte ; Stenderup, Jørgen and Piskur, Jure LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 106
- issue
- 8
- pages
- 2688 - 2693
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000263652900041
- scopus:62449137037
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.0809793106
- language
- English
- LU publication?
- yes
- id
- e058e8b0-a66f-4e63-8306-6a0a0bc6ca5a (old id 1302741)
- date added to LUP
- 2016-04-01 12:00:02
- date last changed
- 2022-02-11 00:36:51
@article{e058e8b0-a66f-4e63-8306-6a0a0bc6ca5a,
abstract = {{In eukaryotes, the number and rough organization of chromosomes is well preserved within isolates of the same species. Novel chromosomes and loss of chromosomes are infrequent and usually associated with pathological events. Here, we analyzed 40 pathogenic isolates of a haploid and asexual yeast, Candida glabrata, for their genome structure and stability. This organism has recently become the second most prevalent yeast pathogen in humans. Although the gene sequences were well conserved among different strains, their chromosome structures differed drastically. The most frequent events reshaping chromosomes were translocations of chromosomal arms. However, also larger segmental duplications were frequent and occasionally we observed novel chromosomes. Apparently, this yeast can generate a new chromosome by duplication of chromosome segments carrying a centromere and subsequently adding novel telomeric ends. We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot.}},
author = {{Poláková, Silvia and Blume, Christian and Zárate, Julián Alvarez and Mentel, Marek and Jørck-Ramberg, Dorte and Stenderup, Jørgen and Piskur, Jure}},
issn = {{1091-6490}},
language = {{eng}},
number = {{8}},
pages = {{2688--2693}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata.}},
url = {{http://dx.doi.org/10.1073/pnas.0809793106}},
doi = {{10.1073/pnas.0809793106}},
volume = {{106}},
year = {{2009}},
}