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Transplantation of mesenchymal stem cells : A future therapy for Parkinson's disease?

Anisimov, Sergey V. LU and Paul, Gesine LU (2014) In Future Neurology 9(4). p.475-486
Abstract

Parkinson's disease (PD) is a common, progressive neurodegenerative disorder associated with a loss of dopaminergic cells in the substantia nigra pars compacta and a lack of dopamine in the striatum. To halt or reverse this disease, neurorestorative approaches or neuroprotective treatments are urgently needed. Recently, the first clinical trials transplanting mesenchymal stem cells (MSCs) have been performed in PD. MSCs are adult stem cells abundant in several tissues, such as the umbilical cord, the bone marrow, the adipose tissue and other tissues. These cells are multipotent, and able to synthesize and secrete a wide spectrum of biologically active factors. MSCs of various origins have been explored as possible substrates for cell... (More)

Parkinson's disease (PD) is a common, progressive neurodegenerative disorder associated with a loss of dopaminergic cells in the substantia nigra pars compacta and a lack of dopamine in the striatum. To halt or reverse this disease, neurorestorative approaches or neuroprotective treatments are urgently needed. Recently, the first clinical trials transplanting mesenchymal stem cells (MSCs) have been performed in PD. MSCs are adult stem cells abundant in several tissues, such as the umbilical cord, the bone marrow, the adipose tissue and other tissues. These cells are multipotent, and able to synthesize and secrete a wide spectrum of biologically active factors. MSCs of various origins have been explored as possible substrates for cell therapy in PD animal models. In this review, we summarize MSC-based experimental transplantation studies in PD, and discuss biological mechanisms that may explain the effects of MSC seen in PD models. Furthermore, we critically evaluate the recent clinical transplantation trials using MSCs in patients with PD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cell therapy, mesenchymal stem cells, Parkinson's disease, transplantation
in
Future Neurology
volume
9
issue
4
pages
12 pages
publisher
Future Medicine Ltd.
external identifiers
  • scopus:84907258656
ISSN
1479-6708
DOI
10.2217/fnl.14.28
language
English
LU publication?
yes
id
e06c96af-e067-410c-adcd-0035d8025627
date added to LUP
2017-06-27 09:50:47
date last changed
2017-06-27 10:47:11
@article{e06c96af-e067-410c-adcd-0035d8025627,
  abstract     = {<p>Parkinson's disease (PD) is a common, progressive neurodegenerative disorder associated with a loss of dopaminergic cells in the substantia nigra pars compacta and a lack of dopamine in the striatum. To halt or reverse this disease, neurorestorative approaches or neuroprotective treatments are urgently needed. Recently, the first clinical trials transplanting mesenchymal stem cells (MSCs) have been performed in PD. MSCs are adult stem cells abundant in several tissues, such as the umbilical cord, the bone marrow, the adipose tissue and other tissues. These cells are multipotent, and able to synthesize and secrete a wide spectrum of biologically active factors. MSCs of various origins have been explored as possible substrates for cell therapy in PD animal models. In this review, we summarize MSC-based experimental transplantation studies in PD, and discuss biological mechanisms that may explain the effects of MSC seen in PD models. Furthermore, we critically evaluate the recent clinical transplantation trials using MSCs in patients with PD.</p>},
  author       = {Anisimov, Sergey V. and Paul, Gesine},
  issn         = {1479-6708},
  keyword      = {cell therapy,mesenchymal stem cells,Parkinson's disease,transplantation},
  language     = {eng},
  month        = {07},
  number       = {4},
  pages        = {475--486},
  publisher    = {Future Medicine Ltd.},
  series       = {Future Neurology},
  title        = {Transplantation of mesenchymal stem cells : A future therapy for Parkinson's disease?},
  url          = {http://dx.doi.org/10.2217/fnl.14.28},
  volume       = {9},
  year         = {2014},
}