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Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Koh, Ara ; Mannerås-Holm, Louise ; Yunn, Na Oh ; Nilsson, Peter M. LU ; Ryu, Sung Ho ; Molinaro, Antonio ; Perkins, Rosie ; Smith, J. Gustav and Bäckhed, Fredrik (2020) In Cell Metabolism 32(4). p.643-653
Abstract

Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AMPK, diabetes, imidazole propionate, individual variations, metformin, microbial metabolites, microbiota, p38γ
in
Cell Metabolism
volume
32
issue
4
pages
11 pages
publisher
Cell Press
external identifiers
  • pmid:32783890
  • scopus:85090062838
ISSN
1550-4131
DOI
10.1016/j.cmet.2020.07.012
language
English
LU publication?
yes
id
e1326184-217b-4f3c-bb6a-9b779a2f7dc4
date added to LUP
2020-09-25 12:07:14
date last changed
2021-02-17 01:14:37
@article{e1326184-217b-4f3c-bb6a-9b779a2f7dc4,
  abstract     = {<p>Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.</p>},
  author       = {Koh, Ara and Mannerås-Holm, Louise and Yunn, Na Oh and Nilsson, Peter M. and Ryu, Sung Ho and Molinaro, Antonio and Perkins, Rosie and Smith, J. Gustav and Bäckhed, Fredrik},
  issn         = {1550-4131},
  language     = {eng},
  month        = {10},
  number       = {4},
  pages        = {643--653},
  publisher    = {Cell Press},
  series       = {Cell Metabolism},
  title        = {Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation},
  url          = {http://dx.doi.org/10.1016/j.cmet.2020.07.012},
  doi          = {10.1016/j.cmet.2020.07.012},
  volume       = {32},
  year         = {2020},
}