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Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Koh, Ara ; Mannerås-Holm, Louise ; Yunn, Na Oh ; Nilsson, Peter M. LU ; Ryu, Sung Ho ; Molinaro, Antonio ; Perkins, Rosie ; Smith, J. Gustav and Bäckhed, Fredrik (2020) In Cell Metabolism 32(4). p.643-653
Abstract

Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AMPK, diabetes, imidazole propionate, individual variations, metformin, microbial metabolites, microbiota, p38γ
in
Cell Metabolism
volume
32
issue
4
pages
11 pages
publisher
Cell Press
external identifiers
  • scopus:85090062838
  • pmid:32783890
ISSN
1550-4131
DOI
10.1016/j.cmet.2020.07.012
language
English
LU publication?
yes
id
e1326184-217b-4f3c-bb6a-9b779a2f7dc4
date added to LUP
2020-09-25 12:07:14
date last changed
2024-06-26 22:16:04
@article{e1326184-217b-4f3c-bb6a-9b779a2f7dc4,
  abstract     = {{<p>Koh et al. show that imidazole propionate, a microbial metabolite, impairs the glucose-lowering effect of the anti-diabetic drug metformin and inhibits metformin-induced AMPK activation by activating p38γ/Akt/inhibitory AMPK serine phosphorylation. They further show that metformin action is restored by blocking imidazole propionate-activated p38γ.</p>}},
  author       = {{Koh, Ara and Mannerås-Holm, Louise and Yunn, Na Oh and Nilsson, Peter M. and Ryu, Sung Ho and Molinaro, Antonio and Perkins, Rosie and Smith, J. Gustav and Bäckhed, Fredrik}},
  issn         = {{1550-4131}},
  keywords     = {{AMPK; diabetes; imidazole propionate; individual variations; metformin; microbial metabolites; microbiota; p38γ}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{4}},
  pages        = {{643--653}},
  publisher    = {{Cell Press}},
  series       = {{Cell Metabolism}},
  title        = {{Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation}},
  url          = {{http://dx.doi.org/10.1016/j.cmet.2020.07.012}},
  doi          = {{10.1016/j.cmet.2020.07.012}},
  volume       = {{32}},
  year         = {{2020}},
}