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Time-specific and cumulative effects of exposure to parental externalizing behavior on risk for young adult alcohol use disorder

Edwards, Alexis C. LU ; Lönn, Sara L. LU ; Karriker-Jaffe, Katherine J. LU ; Sundquist, Jan LU ; Kendler, Kenneth S. LU and Sundquist, Kristina LU (2017) In Addictive Behaviors 72. p.8-13
Abstract

Background Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. Methods We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries. Logistic regression was used to determine whether the effect of parental EB exposure during different developmental periods differentially impacted children's risk for young adult AUD (ages... (More)

Background Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. Methods We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries. Logistic regression was used to determine whether the effect of parental EB exposure during different developmental periods differentially impacted children's risk for young adult AUD (ages 19–24). In addition, we tested how multiply affected parents and/or sustained exposure to affected parents impacted risk. Results While parental EB increased risk for young adult AUD, timing of exposure did not differentially impact risk. Having a second affected parent increased the risk of AUD additionally, and sustained exposure to parental EB across multiple periods resulted in a higher risk of young adult AUD than exposure in only one period. Conclusions In this well-powered population study, there was no evidence of “sensitive periods” of exposure to national registry-ascertained parental EB with respect to impact on young adult AUD, but sustained exposure was more pathogenic than limited exposure. These findings suggest developmental timing does not meaningfully vary the impact, but rather there is a pervasive risk for development of young adult AUD for children and adolescents exposed to parental EB.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alcohol use disorder, Externalizing behavior, Sensitive period
in
Addictive Behaviors
volume
72
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85015644485
ISSN
0306-4603
DOI
10.1016/j.addbeh.2017.03.002
language
English
LU publication?
yes
id
e137ffa9-3981-4440-b531-dbc3e6a4ed9a
date added to LUP
2018-01-25 08:05:39
date last changed
2018-02-07 11:32:22
@article{e137ffa9-3981-4440-b531-dbc3e6a4ed9a,
  abstract     = {<p>Background Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. Methods We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries. Logistic regression was used to determine whether the effect of parental EB exposure during different developmental periods differentially impacted children's risk for young adult AUD (ages 19–24). In addition, we tested how multiply affected parents and/or sustained exposure to affected parents impacted risk. Results While parental EB increased risk for young adult AUD, timing of exposure did not differentially impact risk. Having a second affected parent increased the risk of AUD additionally, and sustained exposure to parental EB across multiple periods resulted in a higher risk of young adult AUD than exposure in only one period. Conclusions In this well-powered population study, there was no evidence of “sensitive periods” of exposure to national registry-ascertained parental EB with respect to impact on young adult AUD, but sustained exposure was more pathogenic than limited exposure. These findings suggest developmental timing does not meaningfully vary the impact, but rather there is a pervasive risk for development of young adult AUD for children and adolescents exposed to parental EB.</p>},
  author       = {Edwards, Alexis C. and Lönn, Sara L. and Karriker-Jaffe, Katherine J. and Sundquist, Jan and Kendler, Kenneth S. and Sundquist, Kristina},
  issn         = {0306-4603},
  keyword      = {Alcohol use disorder,Externalizing behavior,Sensitive period},
  language     = {eng},
  month        = {09},
  pages        = {8--13},
  publisher    = {Elsevier},
  series       = {Addictive Behaviors},
  title        = {Time-specific and cumulative effects of exposure to parental externalizing behavior on risk for young adult alcohol use disorder},
  url          = {http://dx.doi.org/10.1016/j.addbeh.2017.03.002},
  volume       = {72},
  year         = {2017},
}