Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies
Mattsson-Carlgren, Niklas LU
; Palmqvist, Sebastian
LU
; Blennow, Kaj
LU
and Hansson, Oskar
LU
(2020)
In Nature Communications
11(1).
- Abstract
Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are also increasingly improving patient management in clinical practice. A few key cerebrospinal fluid biomarkers have been robustly associated with neurodegenerative diseases. Several novel biomarkers are very promising, especially blood-based markers. However, many biomarker findings have had low reproducibility despite initial promising results. In this perspective, we identify possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases, with a focus on Alzheimer’s disease. We suggest guidelines for researchers and journal editors, with the... (More)
Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are also increasingly improving patient management in clinical practice. A few key cerebrospinal fluid biomarkers have been robustly associated with neurodegenerative diseases. Several novel biomarkers are very promising, especially blood-based markers. However, many biomarker findings have had low reproducibility despite initial promising results. In this perspective, we identify possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases, with a focus on Alzheimer’s disease. We suggest guidelines for researchers and journal editors, with the aim to improve reproducibility of findings.
(Less)
- author
- Mattsson-Carlgren, Niklas
LU
; Palmqvist, Sebastian
LU
; Blennow, Kaj
LU
and Hansson, Oskar
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 11
- issue
- 1
- article number
- 6252
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:33288742
- scopus:85097279338
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-020-19957-6
- language
- English
- LU publication?
- yes
- id
- e1468b64-f124-491d-af32-07a1468c1f21
- date added to LUP
- 2020-12-15 07:27:17
- date last changed
- 2024-03-20 21:17:37
@article{e1468b64-f124-491d-af32-07a1468c1f21,
abstract = {{<p>Biomarkers have revolutionized scientific research on neurodegenerative diseases, in particular Alzheimer’s disease, transformed drug trial design, and are also increasingly improving patient management in clinical practice. A few key cerebrospinal fluid biomarkers have been robustly associated with neurodegenerative diseases. Several novel biomarkers are very promising, especially blood-based markers. However, many biomarker findings have had low reproducibility despite initial promising results. In this perspective, we identify possible sources for low reproducibility of studies on fluid biomarkers for neurodegenerative diseases, with a focus on Alzheimer’s disease. We suggest guidelines for researchers and journal editors, with the aim to improve reproducibility of findings.</p>}},
author = {{Mattsson-Carlgren, Niklas and Palmqvist, Sebastian and Blennow, Kaj and Hansson, Oskar}},
issn = {{2041-1723}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Nature Communications}},
title = {{Increasing the reproducibility of fluid biomarker studies in neurodegenerative studies}},
url = {{http://dx.doi.org/10.1038/s41467-020-19957-6}},
doi = {{10.1038/s41467-020-19957-6}},
volume = {{11}},
year = {{2020}},
}