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Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting

Giontella, Alice LU orcid ; Sjögren, Marketa LU ; Lotta, Luca A. ; Overton, John D. ; Baras, Aris ; Minuz, Pietro ; Fava, Cristiano LU and Melander, Olle LU orcid (2020) In Hypertension p.169-177
Abstract

The clinical value of the polygenetic component of blood pressure (BP) is commonly questioned. We evaluated a genetic risk score for BP (BP-GRS858), based on the most recently published genome-wide association studies variants that were significantly associated with either systolic BP or diastolic BP, for prediction of hypertension and cardiovascular end points. The genotyping was performed in 2 urban-based prospective cohorts: the Malmö Diet and Cancer (n=29 295) and the Malmö Preventive Project (n=9367) and a weighted BP-GRS858based on 858 SNPs was calculated. At baseline, we found a difference of 9.0 mm Hg (systolic BP) and 4.8 mm Hg (diastolic BP) between the top and the bottom quartile of BP-GRS858.... (More)

The clinical value of the polygenetic component of blood pressure (BP) is commonly questioned. We evaluated a genetic risk score for BP (BP-GRS858), based on the most recently published genome-wide association studies variants that were significantly associated with either systolic BP or diastolic BP, for prediction of hypertension and cardiovascular end points. The genotyping was performed in 2 urban-based prospective cohorts: the Malmö Diet and Cancer (n=29 295) and the Malmö Preventive Project (n=9367) and a weighted BP-GRS858based on 858 SNPs was calculated. At baseline, we found a difference of 9.0 mm Hg (systolic BP) and 4.8 mm Hg (diastolic BP) between the top and the bottom quartile of BP-GRS858. In Malmö Preventive Project, the top versus bottom quartile of BP-GRS858was associated with a doubled risk of incident hypertension (odds ratio, 2.05 [95% CI, 1.75-2.39], P=1.4×10-21), a risk higher than that of body mass index, as evaluated in quartiles. In Malmö Diet and Cancer, significant association was found between the age and sex-adjusted BP-GRS858and the incidence of total cardiovascular events, stroke, coronary artery disease, heart failure, atrial fibrillation, and total mortality. Most of these associations remained significant after adjusting for traditional risk factors, including hypertension. BP-GRS858could contribute predictive information regarding future hypertension, with an effect size comparable to other well-known risk factors such as obesity, and predicts cardiovascular events. Given that the exposure to high polygenetic risk starts at birth, we suggest that the BP-GRS858might be useful to identify children or adolescents who would benefit from early hypertension screening and treatment.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atrial fibrillation, blood pressure, coronary artery disease, genotype, hypertension
in
Hypertension
pages
9 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:33222547
  • scopus:85097828070
ISSN
0194-911X
DOI
10.1161/HYPERTENSIONAHA.120.15449
project
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
language
English
LU publication?
yes
id
e15bf1b6-e810-46f1-ac12-a2ed24639f09
date added to LUP
2021-01-08 13:03:49
date last changed
2024-03-20 22:49:10
@article{e15bf1b6-e810-46f1-ac12-a2ed24639f09,
  abstract     = {{<p>The clinical value of the polygenetic component of blood pressure (BP) is commonly questioned. We evaluated a genetic risk score for BP (BP-GRS<sub>858</sub>), based on the most recently published genome-wide association studies variants that were significantly associated with either systolic BP or diastolic BP, for prediction of hypertension and cardiovascular end points. The genotyping was performed in 2 urban-based prospective cohorts: the Malmö Diet and Cancer (n=29 295) and the Malmö Preventive Project (n=9367) and a weighted BP-GRS<sub>858</sub>based on 858 SNPs was calculated. At baseline, we found a difference of 9.0 mm Hg (systolic BP) and 4.8 mm Hg (diastolic BP) between the top and the bottom quartile of BP-GRS<sub>858</sub>. In Malmö Preventive Project, the top versus bottom quartile of BP-GRS<sub>858</sub>was associated with a doubled risk of incident hypertension (odds ratio, 2.05 [95% CI, 1.75-2.39], P=1.4×10<sup>-21</sup>), a risk higher than that of body mass index, as evaluated in quartiles. In Malmö Diet and Cancer, significant association was found between the age and sex-adjusted BP-GRS<sub>858</sub>and the incidence of total cardiovascular events, stroke, coronary artery disease, heart failure, atrial fibrillation, and total mortality. Most of these associations remained significant after adjusting for traditional risk factors, including hypertension. BP-GRS<sub>858</sub>could contribute predictive information regarding future hypertension, with an effect size comparable to other well-known risk factors such as obesity, and predicts cardiovascular events. Given that the exposure to high polygenetic risk starts at birth, we suggest that the BP-GRS<sub>858</sub>might be useful to identify children or adolescents who would benefit from early hypertension screening and treatment.</p>}},
  author       = {{Giontella, Alice and Sjögren, Marketa and Lotta, Luca A. and Overton, John D. and Baras, Aris and Minuz, Pietro and Fava, Cristiano and Melander, Olle}},
  issn         = {{0194-911X}},
  keywords     = {{atrial fibrillation; blood pressure; coronary artery disease; genotype; hypertension}},
  language     = {{eng}},
  pages        = {{169--177}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Hypertension}},
  title        = {{Clinical Evaluation of the Polygenetic Background of Blood Pressure in the Population-Based Setting}},
  url          = {{http://dx.doi.org/10.1161/HYPERTENSIONAHA.120.15449}},
  doi          = {{10.1161/HYPERTENSIONAHA.120.15449}},
  year         = {{2020}},
}