Studies of different secondary metabolites : Natural products from the mevalonate pathway
(2021)- Abstract
- Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.
Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.
In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.
From Aleurodiscus... (More) - Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.
Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.
In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.
From Aleurodiscus sp., 8 molecules in total were isolated, belonging to the benzofuran, chromane and chromene-type compounds.
From G. rufa no novel molecules were isolated since its chemistry is well known, however, this thesis comprises the use of its enzymatic potential to biotransform synthetic analogues of desoxygaliellalactone into galiellalactone and galiellalactam analogues.
Finally, from the medicinal plant Trichilia adolfi, nine novel limonoids-type natural products were isolated and evaluated as anti-parasitic agents. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e1b5e4a0-ade3-43e5-b5f6-70c615af17e9
- author
- Gonzales Ramirez, Mariela Alejandra LU
- supervisor
-
- Olov Sterner LU
- Sophie Manner LU
- Ulf Ellervik LU
- opponent
-
- Doctor Peña Rodríguez, Luis Manuel, Centro de Investigación Científica de Yucatán, Mérida, Yucatán, México
- organization
- publishing date
- 2021-06-04
- type
- Thesis
- publication status
- published
- subject
- keywords
- Natural products, fungi, Galiellalactone, Galiella rufa, Trichilia adolfi, benzofuran
- pages
- 157 pages
- publisher
- Lund University
- defense location
- Kemicentrum Sal C Join via zoom: https://lu-se.zoom.us/j/69776660302?pwd=Zzg2bnVqbTliUkFpZ1dsdFp6WlJGdz09
- defense date
- 2021-08-26 14:00:00
- ISBN
- 978-91-7895-936-5
- 978-91-7895-935-8
- language
- English
- LU publication?
- yes
- id
- e1b5e4a0-ade3-43e5-b5f6-70c615af17e9
- date added to LUP
- 2021-06-07 09:17:00
- date last changed
- 2021-06-10 11:06:34
@phdthesis{e1b5e4a0-ade3-43e5-b5f6-70c615af17e9, abstract = {{Natural products, also called secondary metabolites, are small molecules that are not involved in main life processes. These can be produced by any living organism and play important roles as chemical weapons, protecting the organism from the competitive environment.<br/>Due to their bioactivity, natural products present in medicinal plants, mushrooms (and other organisms such as bacteria and algae) have been the source of medicine and the inspiration of modern dug discovery since they are characterized by an enormous scaffold diversity and structural complexity.<br/>In the search of new natural products, this thesis comprises the study of natural products from two fungal species, Aleurodiscus sp. and Galiella Rufa.<br/>From Aleurodiscus sp., 8 molecules in total were isolated, belonging to the benzofuran, chromane and chromene-type compounds.<br/>From G. rufa no novel molecules were isolated since its chemistry is well known, however, this thesis comprises the use of its enzymatic potential to biotransform synthetic analogues of desoxygaliellalactone into galiellalactone and galiellalactam analogues.<br/>Finally, from the medicinal plant Trichilia adolfi, nine novel limonoids-type natural products were isolated and evaluated as anti-parasitic agents.}}, author = {{Gonzales Ramirez, Mariela Alejandra}}, isbn = {{978-91-7895-936-5}}, keywords = {{Natural products; fungi; Galiellalactone; Galiella rufa; Trichilia adolfi; benzofuran}}, language = {{eng}}, month = {{06}}, publisher = {{Lund University}}, school = {{Lund University}}, title = {{Studies of different secondary metabolites : Natural products from the mevalonate pathway}}, url = {{https://lup.lub.lu.se/search/files/99001735/Mariela_G_Thesis_E_version.pdf}}, year = {{2021}}, }