Improving lymphopoiesis in aged bone marrow
(2026) In Current Opinion in Hematology 33(4).- Abstract
Purpose of review – Aging is associated with impaired B lymphopoiesis and T lymphopoiesis, contributing to immunosenescence and poor immune recovery. Although this decline can be attributed to intrinsic hematopoietic stem cell aging, growing evidence indicates that lymphoid failure reflects constraints operating across multiple levels of the hematopoietic system. This review frames age-associated lymphopoiesis decline as a systems-level problem and outlines conceptual avenues for therapeutic intervention.Recent findings – Age-associated lymphoid failure is increasingly attributed to inflammatory suppression, dominance of dysfunctional stem and progenitor states, and compromised extramedullary support. These insights provide a framework... (More)
Purpose of review – Aging is associated with impaired B lymphopoiesis and T lymphopoiesis, contributing to immunosenescence and poor immune recovery. Although this decline can be attributed to intrinsic hematopoietic stem cell aging, growing evidence indicates that lymphoid failure reflects constraints operating across multiple levels of the hematopoietic system. This review frames age-associated lymphopoiesis decline as a systems-level problem and outlines conceptual avenues for therapeutic intervention.Recent findings – Age-associated lymphoid failure is increasingly attributed to inflammatory suppression, dominance of dysfunctional stem and progenitor states, and compromised extramedullary support. These insights provide a framework for interventions that restore immune competence by rebalancing hematopoiesis or selectively replacing compromised stem cell function.Summary – Age-associated lymphoid decline arises from coordinated constraints across the bone marrow niche, stem and progenitor composition, and extramedullary lymphoid support, rather than intrinsic stem cell exhaustion alone. Targeting these bottlenecks in a context-dependent manner offers multiple routes to improve lymphopoiesis and restore immune competence in aging.
(Less)
- author
- Konturek-Ciesla, Anna LU and Bryder, David LU
- organization
- publishing date
- 2026-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hematopoietic stem and progenitor cells, immune aging, lymphopoiesis, regeneration
- in
- Current Opinion in Hematology
- volume
- 33
- issue
- 4
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:41861249
- scopus:105037559697
- ISSN
- 1065-6251
- DOI
- 10.1097/MOH.0000000000000923
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, Inc.
- id
- e1d5f4a1-e71e-4b0d-8f3e-99677338c4e0
- date added to LUP
- 2026-07-17 12:47:08
- date last changed
- 2026-07-18 03:00:02
@article{e1d5f4a1-e71e-4b0d-8f3e-99677338c4e0,
abstract = {{<p>Purpose of review – Aging is associated with impaired B lymphopoiesis and T lymphopoiesis, contributing to immunosenescence and poor immune recovery. Although this decline can be attributed to intrinsic hematopoietic stem cell aging, growing evidence indicates that lymphoid failure reflects constraints operating across multiple levels of the hematopoietic system. This review frames age-associated lymphopoiesis decline as a systems-level problem and outlines conceptual avenues for therapeutic intervention.Recent findings – Age-associated lymphoid failure is increasingly attributed to inflammatory suppression, dominance of dysfunctional stem and progenitor states, and compromised extramedullary support. These insights provide a framework for interventions that restore immune competence by rebalancing hematopoiesis or selectively replacing compromised stem cell function.Summary – Age-associated lymphoid decline arises from coordinated constraints across the bone marrow niche, stem and progenitor composition, and extramedullary lymphoid support, rather than intrinsic stem cell exhaustion alone. Targeting these bottlenecks in a context-dependent manner offers multiple routes to improve lymphopoiesis and restore immune competence in aging.</p>}},
author = {{Konturek-Ciesla, Anna and Bryder, David}},
issn = {{1065-6251}},
keywords = {{hematopoietic stem and progenitor cells; immune aging; lymphopoiesis; regeneration}},
language = {{eng}},
number = {{4}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Current Opinion in Hematology}},
title = {{Improving lymphopoiesis in aged bone marrow}},
url = {{http://dx.doi.org/10.1097/MOH.0000000000000923}},
doi = {{10.1097/MOH.0000000000000923}},
volume = {{33}},
year = {{2026}},
}