Frequency- and Phase-Sensitive Magnetomotive Ultrasound Imaging of Superparamagnetic Iron Oxide Nanoparticles
(2013) In IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 60(3). p.481-491- Abstract
- It has recently been demonstrated that superparamagnetic iron oxide nanoparticles can be used as magnetomotive ultrasound contrast agents. A time-varying external magnetic field acts to move the particles and, thus, the nanoparticle-laden tissue. However, the difficulty of distinguishing this magnetomotive motion from undesired movement induced in regions without nanoparticles or other motion artifacts has not been well reported. Using a high-frequency linear-array system, we found that displacements outside nanoparticle-laden regions can be similar in magnitude to those in regions containing nanoparticles. We also found that the displacement outside the nanoparticle regions had a phase shift of approximately p radians relative to that in... (More)
- It has recently been demonstrated that superparamagnetic iron oxide nanoparticles can be used as magnetomotive ultrasound contrast agents. A time-varying external magnetic field acts to move the particles and, thus, the nanoparticle-laden tissue. However, the difficulty of distinguishing this magnetomotive motion from undesired movement induced in regions without nanoparticles or other motion artifacts has not been well reported. Using a high-frequency linear-array system, we found that displacements outside nanoparticle-laden regions can be similar in magnitude to those in regions containing nanoparticles. We also found that the displacement outside the nanoparticle regions had a phase shift of approximately p radians relative to that in the nanoparticle regions. To suppress signals arising from undesirable movements, we developed an algorithm based on quadrature detection and phase gating at the precise frequency of nanoparticle displacement. Thus, clutter at other frequencies can be filtered out, and the processed signal can be color-coded and superimposed on the B-mode image. The median signal-to-clutter ratio improvement using the proposed algorithm was 36 dB compared with simply summing the movement energy at all frequencies. This clutter rejection is a crucial step to move magnetomotive ultrasound imaging of nanoparticles toward in vivo investigations. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3636585
- author
- Evertsson, Maria LU ; Cinthio, Magnus LU ; Fredriksson, Sarah ; Olsson, Fredrik ; Persson, Hans W LU and Jansson, Tomas LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
- volume
- 60
- issue
- 3
- pages
- 481 - 491
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- external identifiers
-
- wos:000316216200005
- scopus:84874891343
- ISSN
- 0885-3010
- DOI
- 10.1109/TUFFC.2013.2591
- language
- English
- LU publication?
- yes
- id
- e215eea7-a3bc-41a8-8cef-7136c1691077 (old id 3636585)
- date added to LUP
- 2016-04-01 09:51:17
- date last changed
- 2022-02-24 19:56:30
@article{e215eea7-a3bc-41a8-8cef-7136c1691077, abstract = {{It has recently been demonstrated that superparamagnetic iron oxide nanoparticles can be used as magnetomotive ultrasound contrast agents. A time-varying external magnetic field acts to move the particles and, thus, the nanoparticle-laden tissue. However, the difficulty of distinguishing this magnetomotive motion from undesired movement induced in regions without nanoparticles or other motion artifacts has not been well reported. Using a high-frequency linear-array system, we found that displacements outside nanoparticle-laden regions can be similar in magnitude to those in regions containing nanoparticles. We also found that the displacement outside the nanoparticle regions had a phase shift of approximately p radians relative to that in the nanoparticle regions. To suppress signals arising from undesirable movements, we developed an algorithm based on quadrature detection and phase gating at the precise frequency of nanoparticle displacement. Thus, clutter at other frequencies can be filtered out, and the processed signal can be color-coded and superimposed on the B-mode image. The median signal-to-clutter ratio improvement using the proposed algorithm was 36 dB compared with simply summing the movement energy at all frequencies. This clutter rejection is a crucial step to move magnetomotive ultrasound imaging of nanoparticles toward in vivo investigations.}}, author = {{Evertsson, Maria and Cinthio, Magnus and Fredriksson, Sarah and Olsson, Fredrik and Persson, Hans W and Jansson, Tomas}}, issn = {{0885-3010}}, language = {{eng}}, number = {{3}}, pages = {{481--491}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, series = {{IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control}}, title = {{Frequency- and Phase-Sensitive Magnetomotive Ultrasound Imaging of Superparamagnetic Iron Oxide Nanoparticles}}, url = {{http://dx.doi.org/10.1109/TUFFC.2013.2591}}, doi = {{10.1109/TUFFC.2013.2591}}, volume = {{60}}, year = {{2013}}, }