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Percutaneous transvenous mitral annuloplasty - Initial human experience with device implantation in the coronary sinus

Webb, JG; Harnek, Jan LU ; Munt, BI; Kimblad, Per Ola LU ; Chandavimol, M; Thompson, CR; Mayo, JR and Solem, Jan Otto LU (2006) In Circulation 113(6). p.851-855
Abstract
Background - Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty. Methods and Results - Five patients with chronic ischemic MR underwent percutaneous transvenous implantation of an annuloplasty device in the coronary sinus. Implantation was successful in 4 patients. Baseline MR in the entire group was grade 3.0 +/- 0.7 and was reduced to grade 1.6 +/- 1.1 at the last postimplantation visit when the device was intact or the last... (More)
Background - Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty. Methods and Results - Five patients with chronic ischemic MR underwent percutaneous transvenous implantation of an annuloplasty device in the coronary sinus. Implantation was successful in 4 patients. Baseline MR in the entire group was grade 3.0 +/- 0.7 and was reduced to grade 1.6 +/- 1.1 at the last postimplantation visit when the device was intact or the last postprocedural visit in the patient in whom the device was not successfully implanted. Separation of the bridge section of the device occurred in 3 of 4 implanted devices and was detected at 28 to 81 days after implantation. There were no postprocedural device-related complications. Conclusions - Percutaneous implantation of a device intended to remodel the mitral annulus is feasible. Initial experience suggests a possible favorable effect on MR. Percutaneous transvenous mitral annuloplasty warrants further evaluation as a less invasive alternative to surgical annuloplasty. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
regurgitation, mitral valve, heart failure, annuloplasty, coronary sinus
in
Circulation
volume
113
issue
6
pages
851 - 855
publisher
Lippincott Williams and Wilkins
external identifiers
  • wos:000235319200017
  • pmid:16461812
  • scopus:33644852948
ISSN
1524-4539
DOI
10.1161/CIRCULATIONAHA.105.591602
language
English
LU publication?
yes
id
e21e0607-151c-41e8-b8db-39a7f4d50a92 (old id 417938)
date added to LUP
2007-10-12 16:04:28
date last changed
2019-03-19 02:28:49
@article{e21e0607-151c-41e8-b8db-39a7f4d50a92,
  abstract     = {Background - Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty. Methods and Results - Five patients with chronic ischemic MR underwent percutaneous transvenous implantation of an annuloplasty device in the coronary sinus. Implantation was successful in 4 patients. Baseline MR in the entire group was grade 3.0 +/- 0.7 and was reduced to grade 1.6 +/- 1.1 at the last postimplantation visit when the device was intact or the last postprocedural visit in the patient in whom the device was not successfully implanted. Separation of the bridge section of the device occurred in 3 of 4 implanted devices and was detected at 28 to 81 days after implantation. There were no postprocedural device-related complications. Conclusions - Percutaneous implantation of a device intended to remodel the mitral annulus is feasible. Initial experience suggests a possible favorable effect on MR. Percutaneous transvenous mitral annuloplasty warrants further evaluation as a less invasive alternative to surgical annuloplasty.},
  author       = {Webb, JG and Harnek, Jan and Munt, BI and Kimblad, Per Ola and Chandavimol, M and Thompson, CR and Mayo, JR and Solem, Jan Otto},
  issn         = {1524-4539},
  keyword      = {regurgitation,mitral valve,heart failure,annuloplasty,coronary sinus},
  language     = {eng},
  number       = {6},
  pages        = {851--855},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Circulation},
  title        = {Percutaneous transvenous mitral annuloplasty - Initial human experience with device implantation in the coronary sinus},
  url          = {http://dx.doi.org/10.1161/CIRCULATIONAHA.105.591602},
  volume       = {113},
  year         = {2006},
}