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Cardiorespiratory dysautonomia in post-COVID-19 condition : Manifestations, mechanisms and management

Fedorowski, Artur LU orcid ; Olsén, Monika Fagevik ; Nikesjö, Frida ; Janson, Christer ; Bruchfeld, Judith ; Lerm, Maria and Hedman, Kristofer (2023) In Journal of Internal Medicine 294(5). p.548-562
Abstract

A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately one out of ten COVID-19 convalescents reports persistent health issues more than three months after initial recovery. This "post-COVID-19 condition" may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay, and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults-particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome (POTS) or airway... (More)

A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately one out of ten COVID-19 convalescents reports persistent health issues more than three months after initial recovery. This "post-COVID-19 condition" may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay, and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults-particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome (POTS) or airway disorders-and explore the evidence for chronic autonomic dysfunction as a potential underlying mechanism. The most plausible hypotheses regarding cellular and molecular mechanisms behind the wide spectrum of observed symptoms-such as lingering viruses, persistent inflammation, impairment in oxygen sensing systems and circulating antibodies directed to blood pressure regulatory components-are discussed. In addition, an overview of currently available pharmacological and non-pharmacological treatment options is presented. This article is protected by copyright. All rights reserved.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Internal Medicine
volume
294
issue
5
pages
15 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85161078798
  • pmid:37183186
ISSN
1365-2796
DOI
10.1111/joim.13652
language
English
LU publication?
yes
additional info
This article is protected by copyright. All rights reserved.
id
e2471ece-5d29-4b5b-9a49-a35ebe37b09f
date added to LUP
2023-05-21 03:30:51
date last changed
2025-11-17 13:34:39
@article{e2471ece-5d29-4b5b-9a49-a35ebe37b09f,
  abstract     = {{<p>A significant proportion of COVID-19 patients experience debilitating symptoms for months after the acute infection. According to recent estimates, approximately one out of ten COVID-19 convalescents reports persistent health issues more than three months after initial recovery. This "post-COVID-19 condition" may include a large variety of symptoms from almost all domains and organs, and for some patients it may mean prolonged sick-leave, homestay, and strongly limited activities of daily life. In this narrative review, we focus on the symptoms and signs of post-COVID-19 condition in adults-particularly those associated with cardiovascular and respiratory systems, such as postural orthostatic tachycardia syndrome (POTS) or airway disorders-and explore the evidence for chronic autonomic dysfunction as a potential underlying mechanism. The most plausible hypotheses regarding cellular and molecular mechanisms behind the wide spectrum of observed symptoms-such as lingering viruses, persistent inflammation, impairment in oxygen sensing systems and circulating antibodies directed to blood pressure regulatory components-are discussed. In addition, an overview of currently available pharmacological and non-pharmacological treatment options is presented. This article is protected by copyright. All rights reserved.</p>}},
  author       = {{Fedorowski, Artur and Olsén, Monika Fagevik and Nikesjö, Frida and Janson, Christer and Bruchfeld, Judith and Lerm, Maria and Hedman, Kristofer}},
  issn         = {{1365-2796}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{5}},
  pages        = {{548--562}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Internal Medicine}},
  title        = {{Cardiorespiratory dysautonomia in post-COVID-19 condition : Manifestations, mechanisms and management}},
  url          = {{http://dx.doi.org/10.1111/joim.13652}},
  doi          = {{10.1111/joim.13652}},
  volume       = {{294}},
  year         = {{2023}},
}