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Prevalence of microspirometry-detected chronic obstructive pulmonary disease in two European cohorts of patients hospitalised for acute myocardial infarction : a cross-sectional study

Parker, William A.E. ; Sundh, Josefin ; Oldgren, Jonas ; Andell, Pontus LU ; Reitan, Christian LU ; Jernberg, Tomas ; Hofmann, Robin ; Mohammad, Moman A. LU orcid ; Erlinge, David LU orcid and Akerblom, Axel , et al. (2025) In BMJ Open 15(5).
Abstract

Objectives To establish the prevalence of clinically significant chronic obstructive pulmonary disease (COPD) and relevant characteristics in individuals with a significant smoking history who are hospitalised for acute myocardial infarction (MI). Design Cross-sectional study. Setting Hospital inpatients at 8 European centres (7 in Sweden, 1 in the UK). Participants 518 men or women (302 in Sweden, 216 in the UK) hospitalised for acute MI, aged 40 years or older, with a smoking history of at least 10 pack-years. Primary and secondary outcome measures The primary outcome was prevalence of detected significant COPD (Global Initiative for Chronic Obstructive Lung Disease stages 2-4), defined as a ratio of forced expiratory volume in 1 and... (More)

Objectives To establish the prevalence of clinically significant chronic obstructive pulmonary disease (COPD) and relevant characteristics in individuals with a significant smoking history who are hospitalised for acute myocardial infarction (MI). Design Cross-sectional study. Setting Hospital inpatients at 8 European centres (7 in Sweden, 1 in the UK). Participants 518 men or women (302 in Sweden, 216 in the UK) hospitalised for acute MI, aged 40 years or older, with a smoking history of at least 10 pack-years. Primary and secondary outcome measures The primary outcome was prevalence of detected significant COPD (Global Initiative for Chronic Obstructive Lung Disease stages 2-4), defined as a ratio of forced expiratory volume in 1 and 6 s (FEV 1 /FEV 6) <0.7 and FEV 1 <80% of the predicted value, measured using microspirometry. Secondary outcome measures were prior diagnosis of COPD, prescription of inhaled corticosteroids (ICS), symptom burden (COPD Assessment Test (CAT)) and blood eosinophil count. Results The prevalence of significant COPD was 91/518 (18% (95% CI 14 to 21)) with no difference between the countries. Of those with detected significant COPD, 69 (76%) had no previous COPD diagnosis. A CAT score >10 was found in 65%, and a blood eosinophil count of ≥100/mm 3 and ≥300/mm 3 was found in 76% and 20%, respectively. Inhaled corticosteroids were used by 15% of the patients. Conclusions In a cohort of patients hospitalised for acute MI in Sweden and the UK, one in five patients with a history of smoking was found to have significant COPD based on microspirometry. Symptom burden was high and treatment rates with ICS low. Among those diagnosed with COPD, three out of four had not been previously diagnosed with COPD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Epidemiology, Myocardial infarction, Pulmonary Disease, Chronic Obstructive, Respiratory Function Test
in
BMJ Open
volume
15
issue
5
article number
e097851
publisher
BMJ Publishing Group
external identifiers
  • pmid:40345691
  • scopus:105005029913
ISSN
2044-6055
DOI
10.1136/bmjopen-2024-097851
language
English
LU publication?
yes
id
e2709db4-6bc8-4366-98ad-c0656f5f4e7e
date added to LUP
2025-08-04 13:04:50
date last changed
2025-08-05 03:00:05
@article{e2709db4-6bc8-4366-98ad-c0656f5f4e7e,
  abstract     = {{<p>Objectives To establish the prevalence of clinically significant chronic obstructive pulmonary disease (COPD) and relevant characteristics in individuals with a significant smoking history who are hospitalised for acute myocardial infarction (MI). Design Cross-sectional study. Setting Hospital inpatients at 8 European centres (7 in Sweden, 1 in the UK). Participants 518 men or women (302 in Sweden, 216 in the UK) hospitalised for acute MI, aged 40 years or older, with a smoking history of at least 10 pack-years. Primary and secondary outcome measures The primary outcome was prevalence of detected significant COPD (Global Initiative for Chronic Obstructive Lung Disease stages 2-4), defined as a ratio of forced expiratory volume in 1 and 6 s (FEV 1 /FEV 6) &lt;0.7 and FEV 1 &lt;80% of the predicted value, measured using microspirometry. Secondary outcome measures were prior diagnosis of COPD, prescription of inhaled corticosteroids (ICS), symptom burden (COPD Assessment Test (CAT)) and blood eosinophil count. Results The prevalence of significant COPD was 91/518 (18% (95% CI 14 to 21)) with no difference between the countries. Of those with detected significant COPD, 69 (76%) had no previous COPD diagnosis. A CAT score &gt;10 was found in 65%, and a blood eosinophil count of ≥100/mm 3 and ≥300/mm 3 was found in 76% and 20%, respectively. Inhaled corticosteroids were used by 15% of the patients. Conclusions In a cohort of patients hospitalised for acute MI in Sweden and the UK, one in five patients with a history of smoking was found to have significant COPD based on microspirometry. Symptom burden was high and treatment rates with ICS low. Among those diagnosed with COPD, three out of four had not been previously diagnosed with COPD.</p>}},
  author       = {{Parker, William A.E. and Sundh, Josefin and Oldgren, Jonas and Andell, Pontus and Reitan, Christian and Jernberg, Tomas and Hofmann, Robin and Mohammad, Moman A. and Erlinge, David and Akerblom, Axel and Lawesson, Sofia Sederstam and Konstantinidis, Kyriakos V. and Lindbäck, Johan and Janson, Christer and Björkenheim, Anna and Elamin, Nadir and Mcmellon, Hannah and Moyle, Bethany and Patel, Mehul and El-Khoury, Jad and Surujbally, Raulin and Storey, Robert F. and James, Stefan K.}},
  issn         = {{2044-6055}},
  keywords     = {{Epidemiology; Myocardial infarction; Pulmonary Disease, Chronic Obstructive; Respiratory Function Test}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{BMJ Publishing Group}},
  series       = {{BMJ Open}},
  title        = {{Prevalence of microspirometry-detected chronic obstructive pulmonary disease in two European cohorts of patients hospitalised for acute myocardial infarction : a cross-sectional study}},
  url          = {{http://dx.doi.org/10.1136/bmjopen-2024-097851}},
  doi          = {{10.1136/bmjopen-2024-097851}},
  volume       = {{15}},
  year         = {{2025}},
}