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Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS)

Storch, Alexander ; Schneider, Christine B. ; Klingelhoefer, Lisa ; Odin, Per LU orcid ; Fuchs, Gerd ; Jost, Wolfgang H. ; Martinez-Martin, Pablo ; Koch, Rainer ; Reichmann, Heinz and Chaudhuri, K. Ray , et al. (2015) In Journal of Neural Transmission 122(12). p.1673-1684
Abstract
Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. Delta NMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 +/- A 9.7... (More)
Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. Delta NMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 +/- A 9.7 years) with mean total NMSS score in On state of 41.5 +/- A 37.6 and in Off state of 75.6 +/- A 42.3 (P < 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and Delta NMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
of life (QoL), Quality, Parkinson's disease, Autonomic dysfunction, Apathy, Depression, Motor complications, Non-motor fluctuations, Non-motor symptoms
in
Journal of Neural Transmission
volume
122
issue
12
pages
1673 - 1684
publisher
Springer
external identifiers
  • wos:000364975300006
  • scopus:84947488327
  • pmid:26264174
ISSN
0300-9564
DOI
10.1007/s00702-015-1437-x
language
English
LU publication?
yes
id
e2bf6a1c-bbfa-4a95-8a4b-30ce546af3b7 (old id 8370676)
date added to LUP
2016-04-01 13:22:00
date last changed
2022-12-11 17:44:12
@article{e2bf6a1c-bbfa-4a95-8a4b-30ce546af3b7,
  abstract     = {{Data on frequency, severity and correlations of NMS with motor complications are only available for a limited number of NMS. The NMS Scale (NMSS) is a validated tool to assess a broad range of NMS, which has not been used in NMS fluctuations. We assessed fluctuations of a broad range of non-motor symptom (NMS) for a 1-month time period in fluctuating Parkinson's disease (PD) in a multicenter cross-sectional study using the NMSS assessing NMS in motor On (NMSSOn) and Off state (NMSSOff) combined with clinical NMS and motor function scoring in 100 fluctuating PD patients. Delta NMSSOn/Off was defined as the differences of NMSS scores between On and Off. Complete NMSS datasets were available from 73 patients (53 % men; age: 68.2 +/- A 9.7 years) with mean total NMSS score in On state of 41.5 +/- A 37.6 and in Off state of 75.6 +/- A 42.3 (P &lt; 0.001). Scores were higher in Off compared to On state for all domains except for domain "perceptual problems/hallucinations" (P = 0.608). Clinimetric properties of the NMSS were similar to those reported previously for NMS assessments independent of motor oscillations. NMSSOn, NMSSOff and Delta NMSSOn/Off showed weak to moderate correlations with demographics, indicators of motor symptom severity as well as with other measures of NMS, depression and quality of life. Correlations of NMSS items/domains with independent measures of related constructs were weak to moderate. In conclusion, when assessed with the NMSS, a broad range of NMS fluctuate with motor oscillations, but these fluctuations do neither correlate with motor function nor with measures of disease progression.}},
  author       = {{Storch, Alexander and Schneider, Christine B. and Klingelhoefer, Lisa and Odin, Per and Fuchs, Gerd and Jost, Wolfgang H. and Martinez-Martin, Pablo and Koch, Rainer and Reichmann, Heinz and Chaudhuri, K. Ray and Ebersbach, Georg}},
  issn         = {{0300-9564}},
  keywords     = {{of life (QoL); Quality; Parkinson's disease; Autonomic dysfunction; Apathy; Depression; Motor complications; Non-motor fluctuations; Non-motor symptoms}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1673--1684}},
  publisher    = {{Springer}},
  series       = {{Journal of Neural Transmission}},
  title        = {{Quantitative assessment of non-motor fluctuations in Parkinson's disease using the Non-Motor Symptoms Scale (NMSS)}},
  url          = {{http://dx.doi.org/10.1007/s00702-015-1437-x}},
  doi          = {{10.1007/s00702-015-1437-x}},
  volume       = {{122}},
  year         = {{2015}},
}