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B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches

Biram, Adi ; Winter, Eitan ; Denton, Alice E. ; Zaretsky, Irina ; Dassa, Bareket ; Bemark, Mats LU orcid ; Linterman, Michelle A. ; Yaari, Gur and Shulman, Ziv (2020) In Cell Reports 30(6). p.5-1922
Abstract

SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.

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author
; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
antibody, B cells, clonal diversification, germinal center, IgA, Peyer's patches, plasma cells, SAP, T follicular helper cells
in
Cell Reports
volume
30
issue
6
pages
5 - 1922
publisher
Cell Press
external identifiers
  • scopus:85079170606
  • pmid:32049020
ISSN
2211-1247
DOI
10.1016/j.celrep.2020.01.032
language
English
LU publication?
no
additional info
Publisher Copyright: © 2020 The Authors
id
e2c9799b-fcb4-425b-be75-bc17ba8a7303
date added to LUP
2023-11-28 10:10:42
date last changed
2024-06-20 18:05:00
@article{e2c9799b-fcb4-425b-be75-bc17ba8a7303,
  abstract     = {{<p>SAP is required for proper T cell help in germinal centers (GCs). Biram et al. show that SAP-independent GCs are formed within Peyer's patches. These GCs host highly diversified clones that are subjected to mild selection forces, demonstrating that clonal diversification can be uncoupled from clonal selection in chronic GCs.</p>}},
  author       = {{Biram, Adi and Winter, Eitan and Denton, Alice E. and Zaretsky, Irina and Dassa, Bareket and Bemark, Mats and Linterman, Michelle A. and Yaari, Gur and Shulman, Ziv}},
  issn         = {{2211-1247}},
  keywords     = {{antibody; B cells; clonal diversification; germinal center; IgA; Peyer's patches; plasma cells; SAP; T follicular helper cells}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{6}},
  pages        = {{5--1922}},
  publisher    = {{Cell Press}},
  series       = {{Cell Reports}},
  title        = {{B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches}},
  url          = {{http://dx.doi.org/10.1016/j.celrep.2020.01.032}},
  doi          = {{10.1016/j.celrep.2020.01.032}},
  volume       = {{30}},
  year         = {{2020}},
}