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Progress and outlook of inorganic nanoparticles for delivery of nucleic acid sequences related to orthopedic pathologies : A review

Wagner, Darcy E. LU and Bhaduri, Sarit B. (2012) In Tissue Engineering - Part B: Reviews 18(1). p.1-14
Abstract

The anticipated growth in the aging population will drastically increase medical needs of society; of which, one of the largest components will undoubtedly be from orthopedic-related pathologies. There are several proposed solutions being investigated to cost-effectively prepare for the future-pharmaceuticals, implant devices, cell and gene therapies, or some combination thereof. Gene therapy is one of the more promising possibilities because it seeks to correct the root of the problem, thereby minimizing treatment duration and cost. Currently, viral vectors have shown the highest efficacies, but immunological concerns remain. Nonviral methods show reduced immune responses but are regarded as less efficient. The nonviral paradigms... (More)

The anticipated growth in the aging population will drastically increase medical needs of society; of which, one of the largest components will undoubtedly be from orthopedic-related pathologies. There are several proposed solutions being investigated to cost-effectively prepare for the future-pharmaceuticals, implant devices, cell and gene therapies, or some combination thereof. Gene therapy is one of the more promising possibilities because it seeks to correct the root of the problem, thereby minimizing treatment duration and cost. Currently, viral vectors have shown the highest efficacies, but immunological concerns remain. Nonviral methods show reduced immune responses but are regarded as less efficient. The nonviral paradigms consist of mechanical and chemical approaches. While organic-based materials have been used more frequently in particle-based methods, inorganic materials capable of delivery have distinct advantages, especially advantageous in orthopedic applications. The inorganic gene therapy field is highly interdisciplinary in nature, and requires assimilation of knowledge across the broad fields of cell biology, biochemistry, molecular genetics, materials science, and clinical medicine. This review provides an overview of the role each area plays in orthopedic gene therapy as well as possible future directions for the field.

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author
publishing date
type
Contribution to journal
publication status
published
in
Tissue Engineering - Part B: Reviews
volume
18
issue
1
pages
14 pages
publisher
Mary Ann Liebert Inc.
external identifiers
  • scopus:84856151412
ISSN
1937-3368
DOI
10.1089/ten.teb.2011.0081
language
English
LU publication?
no
id
e2caaa3a-b468-41d5-8043-138a52f799da
date added to LUP
2017-08-15 15:13:53
date last changed
2017-09-10 05:22:56
@article{e2caaa3a-b468-41d5-8043-138a52f799da,
  abstract     = {<p>The anticipated growth in the aging population will drastically increase medical needs of society; of which, one of the largest components will undoubtedly be from orthopedic-related pathologies. There are several proposed solutions being investigated to cost-effectively prepare for the future-pharmaceuticals, implant devices, cell and gene therapies, or some combination thereof. Gene therapy is one of the more promising possibilities because it seeks to correct the root of the problem, thereby minimizing treatment duration and cost. Currently, viral vectors have shown the highest efficacies, but immunological concerns remain. Nonviral methods show reduced immune responses but are regarded as less efficient. The nonviral paradigms consist of mechanical and chemical approaches. While organic-based materials have been used more frequently in particle-based methods, inorganic materials capable of delivery have distinct advantages, especially advantageous in orthopedic applications. The inorganic gene therapy field is highly interdisciplinary in nature, and requires assimilation of knowledge across the broad fields of cell biology, biochemistry, molecular genetics, materials science, and clinical medicine. This review provides an overview of the role each area plays in orthopedic gene therapy as well as possible future directions for the field.</p>},
  author       = {Wagner, Darcy E. and Bhaduri, Sarit B.},
  issn         = {1937-3368},
  language     = {eng},
  month        = {02},
  number       = {1},
  pages        = {1--14},
  publisher    = {Mary Ann Liebert Inc.},
  series       = {Tissue Engineering - Part B: Reviews},
  title        = {Progress and outlook of inorganic nanoparticles for delivery of nucleic acid sequences related to orthopedic pathologies : A review},
  url          = {http://dx.doi.org/10.1089/ten.teb.2011.0081},
  volume       = {18},
  year         = {2012},
}