Human gut-associated lymphoid tissues (GALT); diversity, structure, and function
(2021) In Mucosal Immunology- Abstract
Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's patches of the ileum, the vermiform appendix, and the numerous isolated lymphoid follicles (ILF) which are distributed along the length of the intestine. Our current understanding of GALT diversity and function derives primarily from studies in mice, and the relevance of many of these findings to human GALT remains unclear. Here we review our current understanding of human GALT diversity, structure, and composition as well as their potential for regulating intestinal immune responses during homeostasis and inflammatory bowel disease (IBD). Finally, we outline... (More)
Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's patches of the ileum, the vermiform appendix, and the numerous isolated lymphoid follicles (ILF) which are distributed along the length of the intestine. Our current understanding of GALT diversity and function derives primarily from studies in mice, and the relevance of many of these findings to human GALT remains unclear. Here we review our current understanding of human GALT diversity, structure, and composition as well as their potential for regulating intestinal immune responses during homeostasis and inflammatory bowel disease (IBD). Finally, we outline some key remaining questions regarding human GALT, the answers to which will advance our understanding of intestinal immune responses and provide potential opportunities to improve the treatment of intestinal diseases.
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- author
- Mörbe, Urs M LU ; Jørgensen, Peter B ; Fenton, Thomas M ; von Burg, Nicole ; Riis, Lene B ; Spencer, Jo and Agace, William W LU
- organization
- publishing date
- 2021-03-22
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mucosal Immunology
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85103200580
- pmid:33753873
- ISSN
- 1933-0219
- DOI
- 10.1038/s41385-021-00389-4
- language
- English
- LU publication?
- yes
- additional info
- These authors contributed equally: Urs M. Mörbe, Peter B. Jørgensen, Thomas M. Fenton
- id
- e333dfd3-add6-4b42-8f4f-79fb27880b46
- date added to LUP
- 2021-03-26 09:47:17
- date last changed
- 2024-05-05 03:26:00
@article{e333dfd3-add6-4b42-8f4f-79fb27880b46,
abstract = {{<p>Gut-associated lymphoid tissues (GALT) are the key antigen sampling and adaptive immune inductive sites within the intestinal wall. Human GALT includes the multi-follicular Peyer's patches of the ileum, the vermiform appendix, and the numerous isolated lymphoid follicles (ILF) which are distributed along the length of the intestine. Our current understanding of GALT diversity and function derives primarily from studies in mice, and the relevance of many of these findings to human GALT remains unclear. Here we review our current understanding of human GALT diversity, structure, and composition as well as their potential for regulating intestinal immune responses during homeostasis and inflammatory bowel disease (IBD). Finally, we outline some key remaining questions regarding human GALT, the answers to which will advance our understanding of intestinal immune responses and provide potential opportunities to improve the treatment of intestinal diseases.</p>}},
author = {{Mörbe, Urs M and Jørgensen, Peter B and Fenton, Thomas M and von Burg, Nicole and Riis, Lene B and Spencer, Jo and Agace, William W}},
issn = {{1933-0219}},
language = {{eng}},
month = {{03}},
publisher = {{Nature Publishing Group}},
series = {{Mucosal Immunology}},
title = {{Human gut-associated lymphoid tissues (GALT); diversity, structure, and function}},
url = {{http://dx.doi.org/10.1038/s41385-021-00389-4}},
doi = {{10.1038/s41385-021-00389-4}},
year = {{2021}},
}