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Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles

Wagner, Darcy E. LU ; Lawrence, Joseph and Bhaduri, Sarit B. (2013) In Journal of Materials Research 28(22). p.3119-3129
Abstract

Calcium phosphates (CaPs) are major chemical constituents of mammalian bone. Their osteoconductivity in vitro and in vivo has encouraged their use in biomaterial applications such as implant materials and drug delivery. High aspect ratio nanoparticles are attractive for many biomedical applications; however, precise control of the phase and morphology is challenging. The impact of fuel-to-oxidant ratio, pH, and cation chemistry on morphology and phase was studied for CaP-based compositions by microwave-assisted solution combustion synthesis (MASCS) in a urea-nitrate (fuel-oxidant) system. An initial calcium to phosphate ratio of 1.5 was used. Highly crystalline hydroxyapatite (HA) and biphasic CaP nanoparticle compositions were produced... (More)

Calcium phosphates (CaPs) are major chemical constituents of mammalian bone. Their osteoconductivity in vitro and in vivo has encouraged their use in biomaterial applications such as implant materials and drug delivery. High aspect ratio nanoparticles are attractive for many biomedical applications; however, precise control of the phase and morphology is challenging. The impact of fuel-to-oxidant ratio, pH, and cation chemistry on morphology and phase was studied for CaP-based compositions by microwave-assisted solution combustion synthesis (MASCS) in a urea-nitrate (fuel-oxidant) system. An initial calcium to phosphate ratio of 1.5 was used. Highly crystalline hydroxyapatite (HA) and biphasic CaP nanoparticle compositions were produced as confirmed by x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. MASCS was capable of synthesizing high aspect ratio (∼5 to 20) single and biphasic CaP nanoparticles with diameters ranging from 250 to 500 nm and lengths between 2 and 10 μm.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
combustion synthesis, microwave heating, nanoscale
in
Journal of Materials Research
volume
28
issue
22
pages
3119 - 3129
publisher
Materials Research Society
external identifiers
  • scopus:84888181569
ISSN
0884-2914
DOI
10.1557/jmr.2013.314
language
English
LU publication?
no
id
e36fd155-b104-44cd-82ea-a93d22f280e6
date added to LUP
2017-08-15 15:13:05
date last changed
2018-05-29 11:13:41
@article{e36fd155-b104-44cd-82ea-a93d22f280e6,
  abstract     = {<p>Calcium phosphates (CaPs) are major chemical constituents of mammalian bone. Their osteoconductivity in vitro and in vivo has encouraged their use in biomaterial applications such as implant materials and drug delivery. High aspect ratio nanoparticles are attractive for many biomedical applications; however, precise control of the phase and morphology is challenging. The impact of fuel-to-oxidant ratio, pH, and cation chemistry on morphology and phase was studied for CaP-based compositions by microwave-assisted solution combustion synthesis (MASCS) in a urea-nitrate (fuel-oxidant) system. An initial calcium to phosphate ratio of 1.5 was used. Highly crystalline hydroxyapatite (HA) and biphasic CaP nanoparticle compositions were produced as confirmed by x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. MASCS was capable of synthesizing high aspect ratio (∼5 to 20) single and biphasic CaP nanoparticles with diameters ranging from 250 to 500 nm and lengths between 2 and 10 μm.</p>},
  author       = {Wagner, Darcy E. and Lawrence, Joseph and Bhaduri, Sarit B.},
  issn         = {0884-2914},
  keyword      = {combustion synthesis,microwave heating,nanoscale},
  language     = {eng},
  month        = {11},
  number       = {22},
  pages        = {3119--3129},
  publisher    = {Materials Research Society},
  series       = {Journal of Materials Research},
  title        = {Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles},
  url          = {http://dx.doi.org/10.1557/jmr.2013.314},
  volume       = {28},
  year         = {2013},
}