A mathematical model for measuring blood flow in skeletal muscle with the microdialysis ethanol technique
Wallgren, F ; Amberg, G ; Hickner, R C ; Ekelund, Ulf LU
; Jorfeldt, L
and Henriksson, J
(1995)
In Journal of Applied Physiology
79(2).
p.648-659
- Abstract
- A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoretically calculated results are compared with experiments, and for at least one of the two probe types used good agreement is achieved in a wide range of blood flow and perfusate flow rates. The main uncertainty factor in the theoretical calculations is the diffusivity of ethanol in muscle tissue, and the value for best agreement between theory and... (More)
- A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoretically calculated results are compared with experiments, and for at least one of the two probe types used good agreement is achieved in a wide range of blood flow and perfusate flow rates. The main uncertainty factor in the theoretical calculations is the diffusivity of ethanol in muscle tissue, and the value for best agreement between theory and experiments has been used. Error estimates show that for a constant relative error in the outflow-to-inflow ratio of ethanol in the perfusate, low perfusate flow rates give better predictions of the blood flow. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1109074
- author
- Wallgren, F
; Amberg, G
; Hickner, R C
; Ekelund, Ulf
LU
; Jorfeldt, L
and Henriksson, J
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Applied Physiology
- volume
- 79
- issue
- 2
- pages
- 648 - 659
- publisher
- American Physiological Society
- external identifiers
-
- pmid:7592230
- scopus:0029143655
- ISSN
- 1522-1601
- language
- English
- LU publication?
- no
- id
- e380c0e5-3caf-401a-b855-99a66df3060f (old id 1109074)
- alternative location
- http://jap.physiology.org/cgi/reprint/79/2/648
- date added to LUP
- 2016-04-01 12:06:50
- date last changed
- 2021-01-03 11:36:22
@article{e380c0e5-3caf-401a-b855-99a66df3060f,
abstract = {{A theoretical analysis of the microdialysis ethanol technique in skeletal muscle is presented, and a model governing the transport of ethanol from the microdialysis probe to the capillaries in the muscle tissue is proposed. The model is derived under the assumption of a steady-state situation, and an analytical solution is found for the outflow-to-inflow ratio of ethanol in the perfusate. Theoretically calculated results are compared with experiments, and for at least one of the two probe types used good agreement is achieved in a wide range of blood flow and perfusate flow rates. The main uncertainty factor in the theoretical calculations is the diffusivity of ethanol in muscle tissue, and the value for best agreement between theory and experiments has been used. Error estimates show that for a constant relative error in the outflow-to-inflow ratio of ethanol in the perfusate, low perfusate flow rates give better predictions of the blood flow.}},
author = {{Wallgren, F and Amberg, G and Hickner, R C and Ekelund, Ulf and Jorfeldt, L and Henriksson, J}},
issn = {{1522-1601}},
language = {{eng}},
number = {{2}},
pages = {{648--659}},
publisher = {{American Physiological Society}},
series = {{Journal of Applied Physiology}},
title = {{A mathematical model for measuring blood flow in skeletal muscle with the microdialysis ethanol technique}},
url = {{http://jap.physiology.org/cgi/reprint/79/2/648}},
volume = {{79}},
year = {{1995}},
}