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Effects of chondroitinase ABC on intrathecal and peripheral nerve tissue. An in vivo experimental study on rabbits

Olmarker, K; Danielsen, N LU ; Nordborg, C and Rydevik, B (1991) In Spine 16(1). p.43-45
Abstract

The enzyme chondroitinase ABC has recently been suggested for use in chemonucleolysis. The effects of 200 U ml of chondroitinase ABC were studied on intrathecal and peripheral nerve tissue in rabbits. After the intrathecal (subarachnoid) application of 0.2 ml of either the diluent in the control group (N = 2) or chondroitinase in the study group (N = 4), no neurologic deficit was detected. Compared with the control group, no morphologic changes at the light microscopic level were induced in the spinal cord by chondroitinase. No neurophysiologic differences were detected between tibial nerves after exposure to 1 ml of the diluent (control, N = 8) or chondroitinase (the other leg) for 4 weeks, nor did the study group, compared with the... (More)

The enzyme chondroitinase ABC has recently been suggested for use in chemonucleolysis. The effects of 200 U ml of chondroitinase ABC were studied on intrathecal and peripheral nerve tissue in rabbits. After the intrathecal (subarachnoid) application of 0.2 ml of either the diluent in the control group (N = 2) or chondroitinase in the study group (N = 4), no neurologic deficit was detected. Compared with the control group, no morphologic changes at the light microscopic level were induced in the spinal cord by chondroitinase. No neurophysiologic differences were detected between tibial nerves after exposure to 1 ml of the diluent (control, N = 8) or chondroitinase (the other leg) for 4 weeks, nor did the study group, compared with the control group, show any morphologic changes in the tibial nerves. Because the concentration of chondroitinase ABC tested was approximately 40 times higher than might be used clinically for chemonucleolysis, the present study indicates a wide margin of safety for unwanted side effects on nerve tissue.

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organization
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Contribution to journal
publication status
published
subject
keywords
Animals, Chondroitin Lyases, Intervertebral Disc Chemolysis, Peripheral Nerves, Rabbits, Spinal Nerve Roots, Spinal Nerves, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
Spine
volume
16
issue
1
pages
3 pages
publisher
Lippincott Williams & Wilkins
external identifiers
  • scopus:0026008407
ISSN
0362-2436
language
English
LU publication?
yes
id
e3e79447-41cb-42f6-8602-44e13fd5dc68
date added to LUP
2017-10-13 14:13:28
date last changed
2017-11-29 12:31:59
@article{e3e79447-41cb-42f6-8602-44e13fd5dc68,
  abstract     = {<p>The enzyme chondroitinase ABC has recently been suggested for use in chemonucleolysis. The effects of 200 U ml of chondroitinase ABC were studied on intrathecal and peripheral nerve tissue in rabbits. After the intrathecal (subarachnoid) application of 0.2 ml of either the diluent in the control group (N = 2) or chondroitinase in the study group (N = 4), no neurologic deficit was detected. Compared with the control group, no morphologic changes at the light microscopic level were induced in the spinal cord by chondroitinase. No neurophysiologic differences were detected between tibial nerves after exposure to 1 ml of the diluent (control, N = 8) or chondroitinase (the other leg) for 4 weeks, nor did the study group, compared with the control group, show any morphologic changes in the tibial nerves. Because the concentration of chondroitinase ABC tested was approximately 40 times higher than might be used clinically for chemonucleolysis, the present study indicates a wide margin of safety for unwanted side effects on nerve tissue.</p>},
  author       = {Olmarker, K and Danielsen, N and Nordborg, C and Rydevik, B},
  issn         = {0362-2436},
  keyword      = {Animals,Chondroitin Lyases,Intervertebral Disc Chemolysis,Peripheral Nerves,Rabbits,Spinal Nerve Roots,Spinal Nerves,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {1},
  pages        = {43--45},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Spine},
  title        = {Effects of chondroitinase ABC on intrathecal and peripheral nerve tissue. An in vivo experimental study on rabbits},
  volume       = {16},
  year         = {1991},
}