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Corticosteroids or Not for Postoperative Nausea : A Double-Blinded Randomized Study

Nordin, L.; Nordlund, A.; Lindqvist, Andreas LU ; Gislason, H. and Hedenbro, J. L. LU (2016) In Journal of Gastrointestinal Surgery 20(8). p.1517-1522
Abstract

Background: Postoperative nausea and vomiting (PONV) is common after general anaesthesia, and corticosteroids are used in many protocols for enhanced recovery after surgery (ERAS). However, surgical techniques are developing, and ERAS protocols need to be reevaluated from time to time. Patients and method: In this study, we compared the effects of oral vs. parenteral corticosteroid administration on postoperative nausea. Elective Roux-y-gastric bypass (RYGB) patients were randomly assigned to either 8 mg betamethasone orally (n = 50) or parentally (n = 25) or as controls (n = 25), in a double-blind design. PONV risk factors were noted. All patients had the same anaesthetic technique. Data were collected at baseline, on arrival to the... (More)

Background: Postoperative nausea and vomiting (PONV) is common after general anaesthesia, and corticosteroids are used in many protocols for enhanced recovery after surgery (ERAS). However, surgical techniques are developing, and ERAS protocols need to be reevaluated from time to time. Patients and method: In this study, we compared the effects of oral vs. parenteral corticosteroid administration on postoperative nausea. Elective Roux-y-gastric bypass (RYGB) patients were randomly assigned to either 8 mg betamethasone orally (n = 50) or parentally (n = 25) or as controls (n = 25), in a double-blind design. PONV risk factors were noted. All patients had the same anaesthetic technique. Data were collected at baseline, on arrival to the recovery room (RR) and at five more time points during the first 24 h. Nausea and tiredness were patient assessed using visual analogue scales; rescue drug consumption was recorded. Results: Operation time was 30–40 min. Neither demographics nor risk factors for nausea differed between groups. Neither peak values for nor total amount of nausea differed between groups. The number of supplemental injections was the same for all groups. Comments: In a setting of modern laparoscopic RYGB, the value of betamethasone in preventing PONV seems to be limited. ERAS protocols may need re-evaluation.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anaesthesia, Betamethasone, Corticosteroids, ERAS, Gastric bypass, Laparoscopy, Nausea, PONV, Tiredness
in
Journal of Gastrointestinal Surgery
volume
20
issue
8
pages
1517 - 1522
publisher
Springer
external identifiers
  • Scopus:84969802911
  • WOS:000379528800013
ISSN
1091-255X
DOI
10.1007/s11605-016-3166-3
language
English
LU publication?
yes
id
e415223e-fe1a-4d3e-8720-b69b2f283f34
date added to LUP
2016-06-17 16:09:11
date last changed
2017-01-01 08:28:19
@article{e415223e-fe1a-4d3e-8720-b69b2f283f34,
  abstract     = {<p>Background: Postoperative nausea and vomiting (PONV) is common after general anaesthesia, and corticosteroids are used in many protocols for enhanced recovery after surgery (ERAS). However, surgical techniques are developing, and ERAS protocols need to be reevaluated from time to time. Patients and method: In this study, we compared the effects of oral vs. parenteral corticosteroid administration on postoperative nausea. Elective Roux-y-gastric bypass (RYGB) patients were randomly assigned to either 8 mg betamethasone orally (n = 50) or parentally (n = 25) or as controls (n = 25), in a double-blind design. PONV risk factors were noted. All patients had the same anaesthetic technique. Data were collected at baseline, on arrival to the recovery room (RR) and at five more time points during the first 24 h. Nausea and tiredness were patient assessed using visual analogue scales; rescue drug consumption was recorded. Results: Operation time was 30–40 min. Neither demographics nor risk factors for nausea differed between groups. Neither peak values for nor total amount of nausea differed between groups. The number of supplemental injections was the same for all groups. Comments: In a setting of modern laparoscopic RYGB, the value of betamethasone in preventing PONV seems to be limited. ERAS protocols may need re-evaluation.</p>},
  author       = {Nordin, L. and Nordlund, A. and Lindqvist, Andreas and Gislason, H. and Hedenbro, J. L.},
  issn         = {1091-255X},
  keyword      = {Anaesthesia,Betamethasone,Corticosteroids,ERAS,Gastric bypass,Laparoscopy,Nausea,PONV,Tiredness},
  language     = {eng},
  month        = {05},
  number       = {8},
  pages        = {1517--1522},
  publisher    = {Springer},
  series       = {Journal of Gastrointestinal Surgery},
  title        = {Corticosteroids or Not for Postoperative Nausea : A Double-Blinded Randomized Study},
  url          = {http://dx.doi.org/10.1007/s11605-016-3166-3},
  volume       = {20},
  year         = {2016},
}