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Blood cadmium concentration and risk of subarachnoid haemorrhage

Söderholm, Martin LU ; Borné, Yan LU ; Hedblad, Bo LU ; Persson, Margaretha LU orcid ; Barregard, Lars and Engström, Gunnar LU (2020) In Environmental Research 180. p.108826-108826
Abstract

BACKGROUND: Cadmium is a toxic metal and exposure is mainly from diet and tobacco smoke. Cadmium is accumulated in blood vessels and may reduce synthesis of procollagen and inhibit proliferation of vascular smooth muscle cells. High blood cadmium has been associated with increased risk of myocardial infarction, stroke and unruptured intracranial aneurysms. We examined whether blood cadmium increase the risk of subarachnoid haemorrhage (SAH).

METHODS: The Malmö Diet and Cancer cohort (n = 28,449) was examined in 1991-1996 and blood samples were taken. Incidence of SAH was followed up to 2014. Cadmium was measured in stored blood samples from incident SAH cases and matched controls (n = 93 vs n = 276) and odds ratio (OR) for SAH was... (More)

BACKGROUND: Cadmium is a toxic metal and exposure is mainly from diet and tobacco smoke. Cadmium is accumulated in blood vessels and may reduce synthesis of procollagen and inhibit proliferation of vascular smooth muscle cells. High blood cadmium has been associated with increased risk of myocardial infarction, stroke and unruptured intracranial aneurysms. We examined whether blood cadmium increase the risk of subarachnoid haemorrhage (SAH).

METHODS: The Malmö Diet and Cancer cohort (n = 28,449) was examined in 1991-1996 and blood samples were taken. Incidence of SAH was followed up to 2014. Cadmium was measured in stored blood samples from incident SAH cases and matched controls (n = 93 vs n = 276) and odds ratio (OR) for SAH was assessed in a nested case control design.

RESULTS: Subjects with cadmium concentration in the highest quartile had increased risk of SAH compared to those in the first quartile (OR: 3.22, 95%CI: 1.67-6.22). However, after adjusting for smoking, results were weakened and non-significant (OR: 1.57, 95%CI: 0.51-4.80).

CONCLUSIONS: Cadmium concentration was associated with increased risk of SAH but this association was largely explained by smoking. Whether cadmium in tobacco may contribute to the vascular pathology and increased risk of SAH in smokers should be further studied.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Research
volume
180
pages
108826 - 108826
publisher
Elsevier
external identifiers
  • scopus:85073608509
  • pmid:31654906
ISSN
1096-0953
DOI
10.1016/j.envres.2019.108826
language
English
LU publication?
yes
additional info
Copyright © 2019 Elsevier Inc. All rights reserved.
id
e41a5352-b66b-489e-ae7d-f8f70382b1d0
date added to LUP
2020-03-18 10:49:02
date last changed
2024-04-17 05:09:12
@article{e41a5352-b66b-489e-ae7d-f8f70382b1d0,
  abstract     = {{<p>BACKGROUND: Cadmium is a toxic metal and exposure is mainly from diet and tobacco smoke. Cadmium is accumulated in blood vessels and may reduce synthesis of procollagen and inhibit proliferation of vascular smooth muscle cells. High blood cadmium has been associated with increased risk of myocardial infarction, stroke and unruptured intracranial aneurysms. We examined whether blood cadmium increase the risk of subarachnoid haemorrhage (SAH).</p><p>METHODS: The Malmö Diet and Cancer cohort (n = 28,449) was examined in 1991-1996 and blood samples were taken. Incidence of SAH was followed up to 2014. Cadmium was measured in stored blood samples from incident SAH cases and matched controls (n = 93 vs n = 276) and odds ratio (OR) for SAH was assessed in a nested case control design.</p><p>RESULTS: Subjects with cadmium concentration in the highest quartile had increased risk of SAH compared to those in the first quartile (OR: 3.22, 95%CI: 1.67-6.22). However, after adjusting for smoking, results were weakened and non-significant (OR: 1.57, 95%CI: 0.51-4.80).</p><p>CONCLUSIONS: Cadmium concentration was associated with increased risk of SAH but this association was largely explained by smoking. Whether cadmium in tobacco may contribute to the vascular pathology and increased risk of SAH in smokers should be further studied.</p>}},
  author       = {{Söderholm, Martin and Borné, Yan and Hedblad, Bo and Persson, Margaretha and Barregard, Lars and Engström, Gunnar}},
  issn         = {{1096-0953}},
  language     = {{eng}},
  pages        = {{108826--108826}},
  publisher    = {{Elsevier}},
  series       = {{Environmental Research}},
  title        = {{Blood cadmium concentration and risk of subarachnoid haemorrhage}},
  url          = {{http://dx.doi.org/10.1016/j.envres.2019.108826}},
  doi          = {{10.1016/j.envres.2019.108826}},
  volume       = {{180}},
  year         = {{2020}},
}